在低剂量率和明亮的室内光线条件下优化闪烁成像。

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-11-21 DOI:10.1088/2057-1976/ad91bb
Alexander P Niver, Petr Bruza, Brian W Pogue
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引用次数: 0

摘要

目的:开发一种用于全身辐照(TBI)期间非接触式表面剂量测定的可靠方法,该方法使用闪烁体材料与照相机光电阴极的最佳配对选择,并且对正常室内照明条件(约 500 Lux)不敏感:为了实现这一目标,我们评估了闪烁体信号与照相机检测到的房间背景比(SBR)的发射对比度,这种对比度是在低剂量率创伤性脑损伤和高房间照明的挑战条件下产生的。共对 9 种快速反应闪烁体、3 种波长转换器和 2 种照相机光电阴极进行了系统测试,以确定最佳组合。评估了室内灯光对闪烁体信号和背景信号的影响,以避免信号饱和,同时保持准确的剂量测量。然后使用带通波长滤波器来减少室内灯光和闪烁体信号的影响:一个闪烁体(EJ262)与一个蓝绿敏感光电阴极照相机和一个 500nm 波长带通滤波器相结合,在最大限度开启室内灯光的情况下,闪烁体的 SBR 达到了 95。需要注意的是,这种设计会拒绝所有患者的切伦科夫光,而切伦科夫光对于患者治疗的可视化是非常有用的。另一种方案保留了切伦科夫信号,但产生的闪烁体信号较少,该方案使用了另一种闪烁体(EJ-260)和红色光电阴极照相机,SBR 为 35,但需要使用窄带通滤波器才能使其在室内环境光下工作,另外,窄带通滤波器也会去除大部分切伦科夫信号:通过适当搭配闪烁体发射光谱和照相机光电阴极灵敏度或光学滤波范围,非接触式闪烁体成像可用于创伤性脑损伤的表面剂量测定。
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Optimized scintillation imaging in low dose rate and bright room light conditions.

Objective. To develop a robust method for non-contact surface dosimetry during Total Body Irradiation (TBI) that uses an optimally paired choice of scintillator material with camera photocathode and can work insensitively to the normal ambient room lighting conditions (∼500 Lux).Approach. This goal was approached by assessing the emission contrast of scintillator signal to background room ratio (SBR) detected by the camera, in the challening conditions of low dose rate TBI with high room lights. A total of 9 fast-response scintillators, 3 wavelength shifters, and 2 camera photocathodes were systematically tested to determine the optimal combination. The effects of room lights on the scintillator signal and the background signal were assessed to avoid signal saturation while retaining accurate dose measurement. A bandpass wavelength filter was then applied to reduce the effects on room lights and scintillator signal.Main Results. One scintillator (EJ262) combined with a blue-green sensitive photocathode camera and a 500 nm band pass filter produced the greatest available scintillator SBR of 95 with maximal room lights on. The caveat is that this design rejects all patient Cherenkov light, which can be useful for visualizing the patient treatment. Another option which retained the Cherenkov signal but produced less available scintillator signal was found with another scintillator (EJ-260) and a red photocathode camera with SBR of 35, but a narrow bandpass filter is required to make it work in ambient room lights, which addition will also remove most of the Cherenkov signal.Significance. Non-contact scintillator imaging can be used for surface dosimetry in TBI with appropriate pairing of scintillator emission spectrum and camera photocathode sensitivity or optical filtering range.

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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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