Jun Wen , Lingzhi Xiong , Shulu Wang , Xiaoguang Qiu , Jianqiao Cui , Fan Peng , Xiang Liu , Jian Lu , Haikuo Bian , Dikang Chen , Jiusheng Chang , Zhengxi Yao , Sheng Fan , Dan Zhou , Ze Li , Jialin Liu , Hongyu Liu , Xu Chen , Ling Chen
{"title":"针对脑胶质瘤的肿瘤电场疗法的颅内电场强度预测和治疗方案分析。","authors":"Jun Wen , Lingzhi Xiong , Shulu Wang , Xiaoguang Qiu , Jianqiao Cui , Fan Peng , Xiang Liu , Jian Lu , Haikuo Bian , Dikang Chen , Jiusheng Chang , Zhengxi Yao , Sheng Fan , Dan Zhou , Ze Li , Jialin Liu , Hongyu Liu , Xu Chen , Ling Chen","doi":"10.1016/j.cmpb.2024.108490","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objective</h3><div>Tumor Electric Field Therapy (TEFT) is a new treatment for glioblastoma cells with significant effect and few side effects. However, it is difficult to directly measure the intracranial electric field generated by TEFT, and the inability to control the electric field intensity distribution in the tumor target area also limits the clinical therapeutic effect of TEFT. It is a safe and effective way to construct an efficient and accurate prediction model of intracranial electric field intensity of TEFT by numerical simulation.</div></div><div><h3>Methods</h3><div>Different from the traditional methods, in this study, the brain tissue was segmented based on the MRI data of patients with retained spatial location information, and the spatial position of the brain tissue was given the corresponding electrical parameters after segmentation. Then, a single geometric model of the head profile with the transducer array is constructed, which is assembled with an electrical parameter matrix containing tissue position information. After applying boundary conditions on the transducer, the intracranial electric field intensity could be solved in the frequency domain. The effects of transducer array mode, load voltage and voltage frequency on the intracranial electric field strength were further analyzed. Finally, planning system software was developed for optimizing TEFT treatment regimens for patients.</div></div><div><h3>Results</h3><div>Experimental validation and comparison with existing results demonstrate the proposed method has a more efficient and pervasive modeling approach with higher computational accuracy while preserving the details of MRI brain tissue structure completely. In the optimization analysis of treatment protocols, it was found that increasing the load voltage could effectively increase the electric field intensity in the target area, while the effect of voltage frequency on the electric field intensity was very limited.</div></div><div><h3>Conclusions</h3><div>The results showed that adjusting the transducer array mode was the key method for making targeted treatment plans. The proposed method is capable prediction of intracranial electric field strength with high accuracy and provide guidance for the design of the TEFT therapy process. This study provides a valuable reference for the application of TEFT in clinical practice.</div></div>","PeriodicalId":10624,"journal":{"name":"Computer methods and programs in biomedicine","volume":"258 ","pages":"Article 108490"},"PeriodicalIF":4.9000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prediction of intracranial electric field strength and analysis of treatment protocols in tumor electric field therapy targeting gliomas of the brain\",\"authors\":\"Jun Wen , Lingzhi Xiong , Shulu Wang , Xiaoguang Qiu , Jianqiao Cui , Fan Peng , Xiang Liu , Jian Lu , Haikuo Bian , Dikang Chen , Jiusheng Chang , Zhengxi Yao , Sheng Fan , Dan Zhou , Ze Li , Jialin Liu , Hongyu Liu , Xu Chen , Ling Chen\",\"doi\":\"10.1016/j.cmpb.2024.108490\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and objective</h3><div>Tumor Electric Field Therapy (TEFT) is a new treatment for glioblastoma cells with significant effect and few side effects. However, it is difficult to directly measure the intracranial electric field generated by TEFT, and the inability to control the electric field intensity distribution in the tumor target area also limits the clinical therapeutic effect of TEFT. It is a safe and effective way to construct an efficient and accurate prediction model of intracranial electric field intensity of TEFT by numerical simulation.</div></div><div><h3>Methods</h3><div>Different from the traditional methods, in this study, the brain tissue was segmented based on the MRI data of patients with retained spatial location information, and the spatial position of the brain tissue was given the corresponding electrical parameters after segmentation. Then, a single geometric model of the head profile with the transducer array is constructed, which is assembled with an electrical parameter matrix containing tissue position information. After applying boundary conditions on the transducer, the intracranial electric field intensity could be solved in the frequency domain. The effects of transducer array mode, load voltage and voltage frequency on the intracranial electric field strength were further analyzed. Finally, planning system software was developed for optimizing TEFT treatment regimens for patients.</div></div><div><h3>Results</h3><div>Experimental validation and comparison with existing results demonstrate the proposed method has a more efficient and pervasive modeling approach with higher computational accuracy while preserving the details of MRI brain tissue structure completely. In the optimization analysis of treatment protocols, it was found that increasing the load voltage could effectively increase the electric field intensity in the target area, while the effect of voltage frequency on the electric field intensity was very limited.</div></div><div><h3>Conclusions</h3><div>The results showed that adjusting the transducer array mode was the key method for making targeted treatment plans. The proposed method is capable prediction of intracranial electric field strength with high accuracy and provide guidance for the design of the TEFT therapy process. This study provides a valuable reference for the application of TEFT in clinical practice.</div></div>\",\"PeriodicalId\":10624,\"journal\":{\"name\":\"Computer methods and programs in biomedicine\",\"volume\":\"258 \",\"pages\":\"Article 108490\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-11-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computer methods and programs in biomedicine\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0169260724004838\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer methods and programs in biomedicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169260724004838","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
Prediction of intracranial electric field strength and analysis of treatment protocols in tumor electric field therapy targeting gliomas of the brain
Background and objective
Tumor Electric Field Therapy (TEFT) is a new treatment for glioblastoma cells with significant effect and few side effects. However, it is difficult to directly measure the intracranial electric field generated by TEFT, and the inability to control the electric field intensity distribution in the tumor target area also limits the clinical therapeutic effect of TEFT. It is a safe and effective way to construct an efficient and accurate prediction model of intracranial electric field intensity of TEFT by numerical simulation.
Methods
Different from the traditional methods, in this study, the brain tissue was segmented based on the MRI data of patients with retained spatial location information, and the spatial position of the brain tissue was given the corresponding electrical parameters after segmentation. Then, a single geometric model of the head profile with the transducer array is constructed, which is assembled with an electrical parameter matrix containing tissue position information. After applying boundary conditions on the transducer, the intracranial electric field intensity could be solved in the frequency domain. The effects of transducer array mode, load voltage and voltage frequency on the intracranial electric field strength were further analyzed. Finally, planning system software was developed for optimizing TEFT treatment regimens for patients.
Results
Experimental validation and comparison with existing results demonstrate the proposed method has a more efficient and pervasive modeling approach with higher computational accuracy while preserving the details of MRI brain tissue structure completely. In the optimization analysis of treatment protocols, it was found that increasing the load voltage could effectively increase the electric field intensity in the target area, while the effect of voltage frequency on the electric field intensity was very limited.
Conclusions
The results showed that adjusting the transducer array mode was the key method for making targeted treatment plans. The proposed method is capable prediction of intracranial electric field strength with high accuracy and provide guidance for the design of the TEFT therapy process. This study provides a valuable reference for the application of TEFT in clinical practice.
期刊介绍：
To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine.
Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.
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