教育与代谢综合征：孟德尔随机研究。

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS Frontiers in Nutrition Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI:10.3389/fnut.2024.1477537

Dong Liu, Zi-Xiang Xu, Xue-Lian Liu, Hai-Ling Yang, Ling-Ling Wang, Yan Li

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引用次数: 0

摘要

目的：代谢综合征（MetS）是一系列疾病的集合，会增加疾病发生的风险，并给患者带来经济负担。然而，教育与代谢综合征之间的因果关系尚不确定。本研究采用孟德尔随机化（MR）方法来阐明教育与 MetS 及其组成部分之间的潜在因果关系：方法：从公共数据库中获取与教育、MetS 及其组成部分相关的单核苷酸多态性（SNPs），并采用逆方差加权法（IVW）进行分析：结果显示：教育程度与 MetS（OR = 0.55，95% CI = 0.48-0.63，p = 2.18E-51）、腰围（OR = 0.80，95% CI = 0.76-0.83，p = 4.98E-33）、高血压（OR = 0.96，95% CI = 0.95-0.97；p = 4.54E-10）、空腹血糖（OR = 0.94，95% CI = 0.91-0.97，p = 7.58E-6）和甘油三酯（OR = 0.83，95% CI = 0.79-0.87，p = 7.87E-18），而与高密度脂蛋白胆固醇（OR = 1.22，95% CI = 1.18-1.25，p = 1.45E-31）呈正相关：本研究结果表明，教育可以降低 MetS 的发病率。

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Education and metabolic syndrome: a Mendelian randomization study.

Aims: The metabolic syndrome (MetS), a collection of conditions that heighten the risk of disease development and impose economic burdens on patients. However, the causal relationship between education and MetS was uncertain. In this study, the Mendelian randomization (MR) method was employed to elucidate the potential causal link between education and the MetS and its components.

Method: Single nucleotide polymorphisms (SNPs) associated with education, MetS, and its components were sourced from a public database, with the inverse variance-weighted (IVW) method utilized for analysis.

Results: Education demonstrated a significant negative correlation with the risk of MetS (OR = 0.55, 95% CI = 0.48-0.63, p = 2.18E-51), waist circumference(OR = 0.80, 95% CI = 0.76-0.83, p = 4.98E-33), hypertension (OR = 0.96, 95% CI = 0.95-0.97; p = 4.54E-10), Fasting blood glucose (OR = 0.94, 95% CI = 0.91-0.97, p = 7.58E-6) and triglycerides (OR = 0.83, 95% CI = 0.79-0.87, p = 7.87E-18) while showing a positive association with high-density lipoprotein cholesterol (OR = 1.22, 95% CI = 1.18-1.25, p = 1.45E-31).

Conclusion: The findings of this study suggest that education can decrease the incidence of MetS.

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.