Bupleurum chinense DC.超滤预处理后的水提取物对大孔树脂吸附的影响。

IF 4.2 2区 化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecules Pub Date : 2024-10-31 DOI:10.3390/molecules29215153
Ruihong Wang, Hongbo Liu, Zhishu Tang, Huaxu Zhu, Huan Liu, Ran Guo, Zhongxing Song, Hongbo Xu, Bo Li, Guolong Li, Yue Zhang
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引用次数: 0

摘要

大孔树脂是一种高效的分离技术,在传统中药(中药)的分离和提纯中发挥着至关重要的作用。然而,由于中药使用的材料复杂,大孔树脂在中药制药中的应用受到严重阻碍。本研究探讨了超滤(UF)膜技术对中药提取物大孔树脂吸附行为的影响。本文将柴胡(Bupleurum chinense DC.(水提取物为例,研究了超滤预处理对大孔树脂吸附总皂苷的影响。研究结果表明,大孔树脂对皂荚属植物水提取物中总皂苷成分的吸附遵循假二阶动力学模型和 Langmuir 模型。吸附的热力学参数,包括焓变和吉布斯自由能均为负值,而熵变为正值。这些结果表明,总皂苷成分在大孔树脂上通过自发的热吸附作用形成了单层吸附层,吸附速率不是由颗粒内扩散速率决定的。用平均截留分子量为 50 kDa 的超滤膜处理后,金银花水提取物中的蛋白质、淀粉、果胶、单宁等杂质含量降低,而总皂苷含量保留了 82.32%。皂苷成分在大孔树脂上的吸附动力学模型保持不变,与二阶动力学模型和 Langmuir 模型一致;二阶动力学模型的吸附速率比原始提取物提高了 1.3 倍,Langmuir 模型在 25 ℃ 下的吸附性能提高了 1.16 倍。该研究表明,超滤技术作为一种预处理方法,可以减少中药提取物对大孔树脂的堵塞,提高大孔树脂的吸附性能。
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Effect of the Total Saponins of Bupleurum chinense DC. Water Extracts Following Ultrafiltration Pretreatment on Macroporous Resin Adsorption.

Macroporous resin is an efficient separation technology that plays a crucial role in the separation and purification of traditional Chinese medicine (TCM). However, the application of macroporous resins in TCM pharmaceuticals is hindered by serious fouling caused by the complex materials used in TCM. This study examines the impact of ultrafiltration (UF) membrane technology on the macroporous resin adsorption behavior of TCM extracts. In this paper, Bupleurum chinense DC. (B. chinense) water extracts were included as an example to study the effect of UF pretreatment on the macroporous resin adsorption of total saponins. The study results indicated that the adsorption of total saponins constituents from the water extracts of B. chinense on the macroporous resin followed the pseudo-second-order kinetic model and the Langmuir model. The thermodynamic parameters of adsorption, including enthalpy changes and Gibbs free energies, were negative, while entropy changes were positive. These results demonstrated that the total saponin components form a monolayer adsorption layer by spontaneous thermal adsorption on the macroporous resin, and that the adsorption rate is not determined by the rate of intraparticle diffusion. Following treatment with a UF membrane with an average molecular weight cut-off of 50 kDa, the protein, starch, pectin, tannin, and other impurities in the water extracts of B. chinense were reduced, while the total saponin content was retained at 82.32%. The adsorption kinetic model of the saponin constituents on the macroporous resin remained unchanged and was consistent with both the second-order kinetic model and the Langmuir model; the adsorption rate of the second-order kinetic model increased by 1.3 times and in the Langmuir model at 25 °C, the adsorption performance improved by 1.16 times compared to the original extracts. This study revealed that UF technology as a pretreatment method can reduce the fouling of macroporous resin by TCM extracts and improve the adsorption performance of macroporous resin.

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来源期刊
Molecules
Molecules 化学-有机化学
CiteScore
7.40
自引率
8.70%
发文量
7524
审稿时长
1.4 months
期刊介绍: Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.
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