{"title":"Glycosparvine A，一种来自 Glycosmis parviflora 叶子的新吲哚生物碱。","authors":"Jing-Ling Ren, Pei-Lian Liu, Hong-Yan Yang, Zhong-Liu Zhou, Zi-Ming Chen, Shou-Yuan Wu","doi":"10.1080/14786419.2024.2426210","DOIUrl":null,"url":null,"abstract":"<p><p>In the course of our ongoing search for biologically active compounds from medicinal plant, the ethyl acetate extract from the leaves of <i>Glycosmis parviflora</i> (Rutaceae) was investigated. Six compounds including a new indole alkaloid, glycosparvine A (<b>1</b>), and five previously known metabolites (<b>2</b>-<b>6</b>) were identified. The structure of the new compound (<b>1</b>) was unambiguously elucidated by spectroscopic analyses, including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration of <b>1</b> was assigned by comparing its experimental ECD spectra with those reported for similar compound in the literature. Compounds <b>3</b> and <b>6</b> exhibited moderate inhibitory effects against acetylcholinesterase (AChE) with IC<sub>50</sub> values of 35.1 and 2.8 mM, respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.9000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glycosparvine A, a new indole alkaloid from the leaves of <i>Glycosmis parviflora</i>.\",\"authors\":\"Jing-Ling Ren, Pei-Lian Liu, Hong-Yan Yang, Zhong-Liu Zhou, Zi-Ming Chen, Shou-Yuan Wu\",\"doi\":\"10.1080/14786419.2024.2426210\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In the course of our ongoing search for biologically active compounds from medicinal plant, the ethyl acetate extract from the leaves of <i>Glycosmis parviflora</i> (Rutaceae) was investigated. Six compounds including a new indole alkaloid, glycosparvine A (<b>1</b>), and five previously known metabolites (<b>2</b>-<b>6</b>) were identified. The structure of the new compound (<b>1</b>) was unambiguously elucidated by spectroscopic analyses, including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration of <b>1</b> was assigned by comparing its experimental ECD spectra with those reported for similar compound in the literature. Compounds <b>3</b> and <b>6</b> exhibited moderate inhibitory effects against acetylcholinesterase (AChE) with IC<sub>50</sub> values of 35.1 and 2.8 mM, respectively.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-6\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-11-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2024.2426210\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2426210","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Glycosparvine A, a new indole alkaloid from the leaves of Glycosmis parviflora.
In the course of our ongoing search for biologically active compounds from medicinal plant, the ethyl acetate extract from the leaves of Glycosmis parviflora (Rutaceae) was investigated. Six compounds including a new indole alkaloid, glycosparvine A (1), and five previously known metabolites (2-6) were identified. The structure of the new compound (1) was unambiguously elucidated by spectroscopic analyses, including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration of 1 was assigned by comparing its experimental ECD spectra with those reported for similar compound in the literature. Compounds 3 and 6 exhibited moderate inhibitory effects against acetylcholinesterase (AChE) with IC50 values of 35.1 and 2.8 mM, respectively.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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