Qinglei Zeng , Yuetongxu Li , Zhaoyu Deng , Gutian Zhang , Chengwei Zhang , Haifeng Huang , Xiaozhou Liu
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Research on the second-harmonic focused ultrasonic device based on micro-bubble contrast agents
Non-invasive, accurate diagnosis and treatment have increasingly gained attention in medical research. The nonlinear response mechanism of ultrasound contrast agents and their medical application have become major topics in ultrasound imaging studies. This paper reports on a second-harmonic focused ultrasonic device based on micro-bubble contrast agents, which is designed to solve the problems associated with a weak second-harmonic intensity. A periodic array of circular holes is embedded in the center of a specifically shaped resin plate, and contrast agents are encapsulated in the circular holes using thin resin tape. The functional mechanism is theoretically explained and experimentally verified. This device enables second-harmonic ultrasound imaging with a higher ultrasonic lateral resolution and signal-to-noise ratio than the conventional system without the device.
期刊介绍：
Ultrasonics is the only internationally established journal which covers the entire field of ultrasound research and technology and all its many applications. Ultrasonics contains a variety of sections to keep readers fully informed and up-to-date on the whole spectrum of research and development throughout the world. Ultrasonics publishes papers of exceptional quality and of relevance to both academia and industry. Manuscripts in which ultrasonics is a central issue and not simply an incidental tool or minor issue, are welcomed.
As well as top quality original research papers and review articles by world renowned experts, Ultrasonics also regularly features short communications, a calendar of forthcoming events and special issues dedicated to topical subjects.
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