Case-control Study: Comparative Evaluation of Bio active Glass (Novabone Putty) and Demineralized Freeze-dried Bone Allograft in the Treatment of Mandibular Furcation Defects.

Aim: The aim of this study was to compare a second-generation bioactive glass putty biomaterial (Novabone putty) against demineralized freeze-dried bone allograft (DFDBA) in mandibular grade II furcation defects.

Materials and methods: Fifteen systematically healthy individuals in the age range of 38-50 years were selected for this split-mouth study. Group I consisting of 15 sites, was treated with DFDBA and group II consisting of 15 sites was treated with Novabone putty (NB putty). The clinical parameters recorded at 0, 3 and 6 months included plaque index (PI), gingival index (GI), probing pocket depth (PPD), relative vertical attachment level (RVAL) and relative horizontal attachment level (RHAL). Standardized intraoral periapical radiographs were taken at all 30 sites pre-and 6 months post-operatively.

Results: Probing pocket depth reduced significantly (p = 0.001) when baseline values were compared to 3 and 6 months postoperatively. In group II mean RVAL changed from 6.56 ± 1.44 at baseline to 4.80 ± 1.14 at 3 months and 4.80 ± 1.33 at 6 months which was found to be highly significant (HS) (p = 0.001). The mean RHAL also showed a significant difference when baseline values were compared to 6 months post-operatively in both the groups. With respect to defect depth and bone density, no significant difference was found between the two groups.

Conclusion: Significant improvement of the clinical parameters were seen in both the groups. As both the groups showed increase in defect fill and bone density, it can be summarized that NB putty seems to have comparable regeneration property to that of DFDBA when used for mandibular grade II furcation defects.

Clinical significance: The ease of use and higher level of biological performance of second-generation bioactive glass putty make it an ideal graft material. How to cite this article: Sen A, Rajan P, Kumar V, et al. Case-control Study: Comparative Evaluation of Bio active Glass (Novabone Putty) and Demineralized Freeze-dried Bone Allograft in the Treatment of Mandibular Furcation Defects. J Contemp Dent Pract 2024;25(7):696-702.