{"title":"运动前和运动中规划序列的皮层区域","authors":"Giacomo Ariani, Mahdiyar Shahbazi, Jörn Diedrichsen","doi":"10.1523/JNEUROSCI.1300-24.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Production of rapid movement sequences relies on preparation before (pre-planning) and during (online planning) movement. Here, we compared these processes and asked whether they recruit different cortical areas. Human participants performed three single-finger and three multi-finger sequences in a delayed movement paradigm while undergoing 7T functional MRI. During preparation, primary motor (M1) and somatosensory (S1) areas showed pre-activation of the first movement, even without increases in overall activation. During production, the temporal summation of activity patterns corresponding to constituent fingers explained activity in these areas (M1 and S1). In contrast, the dorsal premotor cortex (PMd) and anterior superior parietal lobule (aSPL) showed substantial activation during the preparation (pre-planning) of multi-finger compared to single-finger sequences. These regions (PMd and aSPL) were also more active during production of multi-finger sequences, suggesting that pre- and online planning may recruit the same regions. However, we observed small but robust differences between the two contrasts, suggesting distinct contributions to pre- and online planning. Multivariate analysis revealed sequence-specific representations in both PMd and aSPL, which remained stable across both preparation and production phases. Our analyses show that these areas maintain a sequence-specific representation before and during sequence production, likely guiding the execution-related areas in the production of rapid movement sequences.<b>Significance Statement</b> Understanding how the brain orchestrates complex behavior remains a core challenge in human neuroscience. Here, we combine high-resolution neuroimaging and a carefully crafted design to study the neural control of rapid sequential finger movements, like typing or playing the piano. Advancing prior research, we show that the brain areas involved in planning these movements maintain those representations throughout the execution of the sequence. This representational stability across planning and execution suggests an intricate connection between these processes. Our results shed light on the nuanced contributions of different cortical areas to different aspects of coordinating skilled movement. This work is well placed to inform future research in animal models and the development of targeted interventions against movement disorders.</p>","PeriodicalId":50114,"journal":{"name":"Journal of Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cortical areas for planning sequences before and during movement.\",\"authors\":\"Giacomo Ariani, Mahdiyar Shahbazi, Jörn Diedrichsen\",\"doi\":\"10.1523/JNEUROSCI.1300-24.2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Production of rapid movement sequences relies on preparation before (pre-planning) and during (online planning) movement. Here, we compared these processes and asked whether they recruit different cortical areas. Human participants performed three single-finger and three multi-finger sequences in a delayed movement paradigm while undergoing 7T functional MRI. During preparation, primary motor (M1) and somatosensory (S1) areas showed pre-activation of the first movement, even without increases in overall activation. During production, the temporal summation of activity patterns corresponding to constituent fingers explained activity in these areas (M1 and S1). In contrast, the dorsal premotor cortex (PMd) and anterior superior parietal lobule (aSPL) showed substantial activation during the preparation (pre-planning) of multi-finger compared to single-finger sequences. These regions (PMd and aSPL) were also more active during production of multi-finger sequences, suggesting that pre- and online planning may recruit the same regions. However, we observed small but robust differences between the two contrasts, suggesting distinct contributions to pre- and online planning. Multivariate analysis revealed sequence-specific representations in both PMd and aSPL, which remained stable across both preparation and production phases. Our analyses show that these areas maintain a sequence-specific representation before and during sequence production, likely guiding the execution-related areas in the production of rapid movement sequences.<b>Significance Statement</b> Understanding how the brain orchestrates complex behavior remains a core challenge in human neuroscience. Here, we combine high-resolution neuroimaging and a carefully crafted design to study the neural control of rapid sequential finger movements, like typing or playing the piano. Advancing prior research, we show that the brain areas involved in planning these movements maintain those representations throughout the execution of the sequence. This representational stability across planning and execution suggests an intricate connection between these processes. Our results shed light on the nuanced contributions of different cortical areas to different aspects of coordinating skilled movement. This work is well placed to inform future research in animal models and the development of targeted interventions against movement disorders.</p>\",\"PeriodicalId\":50114,\"journal\":{\"name\":\"Journal of Neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1523/JNEUROSCI.1300-24.2024\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1523/JNEUROSCI.1300-24.2024","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Cortical areas for planning sequences before and during movement.
Production of rapid movement sequences relies on preparation before (pre-planning) and during (online planning) movement. Here, we compared these processes and asked whether they recruit different cortical areas. Human participants performed three single-finger and three multi-finger sequences in a delayed movement paradigm while undergoing 7T functional MRI. During preparation, primary motor (M1) and somatosensory (S1) areas showed pre-activation of the first movement, even without increases in overall activation. During production, the temporal summation of activity patterns corresponding to constituent fingers explained activity in these areas (M1 and S1). In contrast, the dorsal premotor cortex (PMd) and anterior superior parietal lobule (aSPL) showed substantial activation during the preparation (pre-planning) of multi-finger compared to single-finger sequences. These regions (PMd and aSPL) were also more active during production of multi-finger sequences, suggesting that pre- and online planning may recruit the same regions. However, we observed small but robust differences between the two contrasts, suggesting distinct contributions to pre- and online planning. Multivariate analysis revealed sequence-specific representations in both PMd and aSPL, which remained stable across both preparation and production phases. Our analyses show that these areas maintain a sequence-specific representation before and during sequence production, likely guiding the execution-related areas in the production of rapid movement sequences.Significance Statement Understanding how the brain orchestrates complex behavior remains a core challenge in human neuroscience. Here, we combine high-resolution neuroimaging and a carefully crafted design to study the neural control of rapid sequential finger movements, like typing or playing the piano. Advancing prior research, we show that the brain areas involved in planning these movements maintain those representations throughout the execution of the sequence. This representational stability across planning and execution suggests an intricate connection between these processes. Our results shed light on the nuanced contributions of different cortical areas to different aspects of coordinating skilled movement. This work is well placed to inform future research in animal models and the development of targeted interventions against movement disorders.
期刊介绍:
JNeurosci (ISSN 0270-6474) is an official journal of the Society for Neuroscience. It is published weekly by the Society, fifty weeks a year, one volume a year. JNeurosci publishes papers on a broad range of topics of general interest to those working on the nervous system. Authors now have an Open Choice option for their published articles