Wenpeng You , Luisa Garcia , Kamal Hezam , Hui Chen (Rita) Chang
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Limited role of biological aging in unhealthy aging: A cross-sectional analysis of global life expectancy and disability data
Background
Biological aging is known to impact quality of life, but its precise role is debated.
Objective
This study explores how biological aging, measured by life expectancy at birth (e0), affects unhealthy aging as indicated by years lost due to disability (YLD).
Methods
Data from international organizations, including e0, YLD, and confounding factors like income, obesity, and urbanization, were analyzed. Correlations were visualized with scatter plots, and associations were assessed using Pearson's and nonparametric methods. Partial, multilevel modelling and multiple regression analyses were conducted to determine e0′s impact on YLD.
Results
e0 strongly correlated with YLD, explaining about 50 % of its variance. After adjusting for confounders, e0’s contribution fell to 12.18 %. Multiple regression identified e0 and urbanization as significant predictors.
Conclusions
Biological aging influences YLD, but its effect diminishes when accounting for other factors, highlighting the need for a comprehensive approach to healthy aging.
期刊介绍：
Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published.
Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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