生物体之间的 RNA 通信激发了创新的生态友好型疾病控制策略

IF 81.3 1区生物学 Q1 CELL BIOLOGY Nature Reviews Molecular Cell Biology Pub Date : 2024-11-15 DOI:10.1038/s41580-024-00807-y

Rachael Hamby, Qiang Cai, Hailing Jin

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引用次数: 0

摘要

有证据表明，RNA 贩运是跨物种和跨王国的一种关键交流机制，但 RNA 如何分泌和贩运以及它们如何在受体生物体内发挥作用仍不清楚。在此，我们将讨论了解生物体间的 RNA 交流如何有助于农业和医学领域的疾病管理。跨物种的宿主-病原体或互利的 RNA 通信，尤其是通过胞外囊泡进行的通信，可以有重要的应用价值，包括农业中的基因沉默和基于 RNA 的疗法。

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RNA communication between organisms inspires innovative eco-friendly strategies for disease control

Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secreted and trafficked and how they function within the recipient organisms remain unclear. Here, we discuss how understanding inter-organismal RNA communication can assist in disease management in both agriculture and medicine. Cross-species host–pathogen or mutualistic RNA communication, especially through extracellular vesicles, can have important applications, including gene silencing in agriculture and RNA-based therapeutics.

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.

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