将猪腕骨作为人类腕骨的潜在临床前动物模型进行生物力学评估。

IF 2.4 3区 医学 Q3 BIOPHYSICS Journal of biomechanics Pub Date : 2024-11-12 DOI:10.1016/j.jbiomech.2024.112429
Madison K. Altieri , Rohit Badida , Quianna M. Vaughan , Janine Molino , Edward Akelman , Joseph J. Crisco
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引用次数: 0

摘要

临床前动物模型有限是阻碍成功治疗腕关节失稳的部分原因。本研究旨在评估尤卡坦小型猪(Yucatan minipig,YP)前肢作为人类腕部潜在临床前动物模型的可能性,方法是在体外对腕关节生物力学进行量化,包括完整状态和两种韧带横断后的状态。使用六轴机器人肌肉骨骼模拟器测定了猪腕部(n = 12,5M,7F)在 28 个运动范围 (ROM) 方向、前屈-上屈和外侧-背侧平移中的生物力学特性。测试在三种条件下进行--完好无损以及连续切断桡侧中间韧带(RIL)和背侧腕间韧带(DIC)后。混合模型用于研究男性和女性样本在方向和条件上的差异。完整的ROM包膜呈椭圆形,朝向尺侧屈曲,最大ROM与屈伸轴线相差约15°。RIL和DIC的横断并没有改变ROM包膜的方向,但是,在RIL和DIC横断后,伸展和桡侧偏离的ROM都有细微的增加。在所有三种测试条件下,中立位时的前伸均大于后仰。在 RIL 和 DIC 条件下,腓骨平移有微妙的增加。这项新颖的研究调查了YP前肢的多方向生物力学。在伸展、桡侧和尺侧偏离等一般方向上的ROM小于人类,而屈曲方向上的ROM则大得多。这些特定的韧带横断对翼手龙前肢的生物力学影响较小。
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Biomechanical evaluation of the porcine carpus as a potential preclinical animal model for the human carpus
Advancing successful treatments for carpal instabilities of the wrist are hindered due, in part, to limited preclinical animal models. The purpose of this study was to evaluate the forelimb of the Yucatan minipig (YP) as a potential preclinical animal model for the human wrist by quantifying carpal biomechanics in vitro in the intact and after two ligament transection conditions. Porcine wrist biomechanics (n = 12, 5M, 7F) were determined in 28 range of motion (ROM) directions, in pronation-supination, and in volar-dorsal translation using a six-axis robotic musculoskeletal simulator. Testing was implemented in three conditions – intact, and after sequential transection of the radial intermediate ligament (RIL) and the dorsal intercarpal ligament (DIC). Mixed models were employed to examine differences in direction and conditions among male and female specimens. The intact ROM envelope was elliptical in shape and oriented toward ulnar flexion with the largest ROM about 15° from the flexion–extension axis. Transection of RIL and DIC did not alter the ROM envelope orientation, however, subtle increases in ROM were observed in extension and radial deviation following transection of both RIL and DIC. Pronation in neutral was greater than supination in all three test conditions. Volar translation increased subtly in the RIL and DIC condition. This novel study investigated the multidirectional biomechanics of the YP forelimb. ROM in the general directions of extension, radial and ulnar deviation were less than in humans, while flexion was substantially larger. These specific ligament transections had minor effects on the biomechanics of the YP forelimb.
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来源期刊
Journal of biomechanics
Journal of biomechanics 生物-工程:生物医学
CiteScore
5.10
自引率
4.20%
发文量
345
审稿时长
1 months
期刊介绍: The Journal of Biomechanics publishes reports of original and substantial findings using the principles of mechanics to explore biological problems. Analytical, as well as experimental papers may be submitted, and the journal accepts original articles, surveys and perspective articles (usually by Editorial invitation only), book reviews and letters to the Editor. The criteria for acceptance of manuscripts include excellence, novelty, significance, clarity, conciseness and interest to the readership. Papers published in the journal may cover a wide range of topics in biomechanics, including, but not limited to: -Fundamental Topics - Biomechanics of the musculoskeletal, cardiovascular, and respiratory systems, mechanics of hard and soft tissues, biofluid mechanics, mechanics of prostheses and implant-tissue interfaces, mechanics of cells. -Cardiovascular and Respiratory Biomechanics - Mechanics of blood-flow, air-flow, mechanics of the soft tissues, flow-tissue or flow-prosthesis interactions. -Cell Biomechanics - Biomechanic analyses of cells, membranes and sub-cellular structures; the relationship of the mechanical environment to cell and tissue response. -Dental Biomechanics - Design and analysis of dental tissues and prostheses, mechanics of chewing. -Functional Tissue Engineering - The role of biomechanical factors in engineered tissue replacements and regenerative medicine. -Injury Biomechanics - Mechanics of impact and trauma, dynamics of man-machine interaction. -Molecular Biomechanics - Mechanical analyses of biomolecules. -Orthopedic Biomechanics - Mechanics of fracture and fracture fixation, mechanics of implants and implant fixation, mechanics of bones and joints, wear of natural and artificial joints. -Rehabilitation Biomechanics - Analyses of gait, mechanics of prosthetics and orthotics. -Sports Biomechanics - Mechanical analyses of sports performance.
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