Zi Kang Meng , Si Min Rao , Yu Kai Hu , Xuan Zhou , Qian Yang , Ren Xiang Tan , Yi Shuang Wang
{"title":"从内生链霉菌 Chartreusis M7 中发现具有细胞毒性的蒽环类衍生多酮。","authors":"Zi Kang Meng , Si Min Rao , Yu Kai Hu , Xuan Zhou , Qian Yang , Ren Xiang Tan , Yi Shuang Wang","doi":"10.1016/j.phytochem.2024.114337","DOIUrl":null,"url":null,"abstract":"<div><div>Endophytic actinomycetes exhibit considerable potential for the production of biologically active metabolites due to their coevolution with plant hosts. In this study, an endophytic <em>Streptomyces chartreusis</em> M7 was isolated from <em>Houttuynia cordata</em> Thunb. Bioactivity-guided investigation of the metabolites produced by this strain led to the identification of thirteen anthracycline-derived polyketides, including five unreported anthraquinones designated streptoquinones A-E (<strong>1</strong>–<strong>5</strong>) and two undescribed angular polyketides named chartins A and B (<strong>6</strong>–<strong>7</strong>) along with six knowns. Their structures were elucidated through comprehensive spectroscopic analysis and ECD calculations. Notably, chartins A (<strong>6</strong>) and B (<strong>7</strong>) feature angular tetracyclic and pentacyclic skeletons, respectively, which have undergone several oxidative rearrangements. Moreover, streptoquinone A (<strong>1</strong>) exhibited moderate cytotoxicity against A549 cells, with an IC<sub>50</sub> value of 4.8 μM.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"230 ","pages":"Article 114337"},"PeriodicalIF":3.2000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Discovery of undescribed anthracycline-derived polyketides with cytotoxicity from endophytic Streptomyces chartreusis M7\",\"authors\":\"Zi Kang Meng , Si Min Rao , Yu Kai Hu , Xuan Zhou , Qian Yang , Ren Xiang Tan , Yi Shuang Wang\",\"doi\":\"10.1016/j.phytochem.2024.114337\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Endophytic actinomycetes exhibit considerable potential for the production of biologically active metabolites due to their coevolution with plant hosts. In this study, an endophytic <em>Streptomyces chartreusis</em> M7 was isolated from <em>Houttuynia cordata</em> Thunb. Bioactivity-guided investigation of the metabolites produced by this strain led to the identification of thirteen anthracycline-derived polyketides, including five unreported anthraquinones designated streptoquinones A-E (<strong>1</strong>–<strong>5</strong>) and two undescribed angular polyketides named chartins A and B (<strong>6</strong>–<strong>7</strong>) along with six knowns. Their structures were elucidated through comprehensive spectroscopic analysis and ECD calculations. Notably, chartins A (<strong>6</strong>) and B (<strong>7</strong>) feature angular tetracyclic and pentacyclic skeletons, respectively, which have undergone several oxidative rearrangements. Moreover, streptoquinone A (<strong>1</strong>) exhibited moderate cytotoxicity against A549 cells, with an IC<sub>50</sub> value of 4.8 μM.</div></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":\"230 \",\"pages\":\"Article 114337\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224003741\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224003741","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Discovery of undescribed anthracycline-derived polyketides with cytotoxicity from endophytic Streptomyces chartreusis M7
Endophytic actinomycetes exhibit considerable potential for the production of biologically active metabolites due to their coevolution with plant hosts. In this study, an endophytic Streptomyces chartreusis M7 was isolated from Houttuynia cordata Thunb. Bioactivity-guided investigation of the metabolites produced by this strain led to the identification of thirteen anthracycline-derived polyketides, including five unreported anthraquinones designated streptoquinones A-E (1–5) and two undescribed angular polyketides named chartins A and B (6–7) along with six knowns. Their structures were elucidated through comprehensive spectroscopic analysis and ECD calculations. Notably, chartins A (6) and B (7) feature angular tetracyclic and pentacyclic skeletons, respectively, which have undergone several oxidative rearrangements. Moreover, streptoquinone A (1) exhibited moderate cytotoxicity against A549 cells, with an IC50 value of 4.8 μM.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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