一名患有类风湿性关节炎的年轻男性突发心源性猝死。

IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Journal of the Pakistan Medical Association Pub Date : 2024-11-01 DOI:10.47391/JPMA.10763
Narae Kim, Sang-Ho Cho, In-Ho Yang
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引用次数: 0

摘要

类风湿性关节炎(RA)会导致冠状动脉粥样硬化,其风险与糖尿病或高血压相似。然而,冠状动脉疾病(CAD)在年轻患者中并不多见,尤其是那些表现为慢性全闭塞(CTO)的患者。我们报告了一例罕见的心脏性猝死中止病例,患者 26 岁,有 6 年 RA 病史。除 RA 外,他没有任何心血管风险因素。通过多模态评估,他被诊断为因近期心肌缺血并伴有 CTO 而导致的严重缺血性心力衰竭(HF)。RA 与易损斑块的形成和血栓形成倾向有关。抗风湿药物被认为可以预防 CAD 的恶化,降低 RA 患者的心血管风险。然而,尽管该患者正在服用抗风湿药物,但仍患有严重的高血压和 CTO。该病例表明,RA 可能是年轻人患 CAD(包括 CTO)的主要危险因素。
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Aborted sudden cardiac death in a young male with rheumatoid arthritis.

Rheumatoid arthritis (RA) causes coronary artery atherosclerosis with a similar risk as diabetes or hypertension. However, coronary artery disease (CAD) is rare in young patients, especially in those presenting as chronic total occlusion (CTO). We report a rare case of aborted sudden cardiac death in a 26-year-old patient with a six-year history of RA. He had no cardiovascular risk factors apart from RA. He was diagnosed with severe ischaemic heart failure (HF) due to recent myocardial ischaemia with CTO, using multimodal evaluation. RA is associated with vulnerable plaque formation and prothrombotic tendencies. Anti-rheumatic drugs are thought to prevent the progression of CAD and reduce cardiovascular risk in patients with RA. However, this patient had severe HF with CTO, despite being on RA medication. This case suggests that RA may be a major risk factor for CAD, including CTO, in young individuals.

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来源期刊
CiteScore
1.10
自引率
11.10%
发文量
983
审稿时长
3-6 weeks
期刊介绍: Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.
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