用gasdermin E武装溶瘤M1病毒可增强乳腺癌的抗肿瘤疗效。

IF 4.6 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES iScience Pub Date : 2024-10-16 eCollection Date: 2024-11-15 DOI:10.1016/j.isci.2024.111148
Xiao-Yu Chen, Ying Liu, Wen-Bo Zhu, Shu-Hao Li, Song Wei, Jing Cai, Yuan Lin, Jian-Kai Liang, Guang-Mei Yan, Li Guo, Cheng Hu
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引用次数: 0

摘要

由gasdermin蛋白(GSDM)N端结构域驱动的热蛋白沉积(Pyroptosis)可通过吸引淋巴细胞进入肿瘤微环境(TME)来促进抗肿瘤免疫。然而,目前的热核素诱导疗法(如药物注射和光疗)仅限于局部治疗,不适合广泛或微小转移病灶。本研究设计了溶瘤 M1 病毒(rM1-mGSDME_FL 和 rM1-mGSDME_NT),以选择性地向肿瘤细胞递送 GSDME。这些改良病毒在乳腺癌模型中增强了肿瘤细胞的死亡,抑制了肿瘤生长,延长了小鼠的存活时间,并促进了免疫细胞的浸润,显示了通过诱导热变态反应的显著抗癌潜力。
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Arming oncolytic M1 virus with gasdermin E enhances antitumor efficacy in breast cancer.

Pyroptosis, driven by the N-terminal domain of gasdermin proteins (GSDM), promotes antitumor immunity by attracting lymphocytes to the tumor microenvironment (TME). However, current pyroptosis-inducing therapies like drug injections and phototherapy are limited to localized treatments, making them unsuitable for widespread or microscopic metastatic lesions. This study engineered oncolytic M1 viruses (rM1-mGSDME_FL and rM1-mGSDME_NT) to selectively deliver GSDME to tumor cells. These modified viruses enhanced tumor cell death in breast cancer models, suppressed tumor growth, extended survival in mice, and boosted immune cell infiltration, demonstrating significant anticancer potential through pyroptosis induction.

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来源期刊
iScience
iScience Multidisciplinary-Multidisciplinary
CiteScore
7.20
自引率
1.70%
发文量
1972
审稿时长
6 weeks
期刊介绍: Science has many big remaining questions. To address them, we will need to work collaboratively and across disciplines. The goal of iScience is to help fuel that type of interdisciplinary thinking. iScience is a new open-access journal from Cell Press that provides a platform for original research in the life, physical, and earth sciences. The primary criterion for publication in iScience is a significant contribution to a relevant field combined with robust results and underlying methodology. The advances appearing in iScience include both fundamental and applied investigations across this interdisciplinary range of topic areas. To support transparency in scientific investigation, we are happy to consider replication studies and papers that describe negative results. We know you want your work to be published quickly and to be widely visible within your community and beyond. With the strong international reputation of Cell Press behind it, publication in iScience will help your work garner the attention and recognition it merits. Like all Cell Press journals, iScience prioritizes rapid publication. Our editorial team pays special attention to high-quality author service and to efficient, clear-cut decisions based on the information available within the manuscript. iScience taps into the expertise across Cell Press journals and selected partners to inform our editorial decisions and help publish your science in a timely and seamless way.
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