天维菌素 B 的晶体结构和降解产物。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2024-11-18 DOI:10.1080/14786419.2024.2429110

Zhen-Yu Wang, Chun-Hui Wu, Xiao-Han Ren, Wei Zhang, Shao-Yong Zhang, Huan Qi, Jun Huang, Ji-Dong Wang, Hui Zhang

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引用次数: 0

摘要

这项工作的目的是研究十维菌素B（TVM B）的晶体结构和降解产物（DPs）。在溶剂体系（MeOH:甲酰胺:H2O=2:5:2）中获得了合适的 TVM B 晶体，并通过单晶 X 射线衍射分析明确了其绝对构型。同时，还开发了一种甲酰胺辅助结晶方法来纯化 TVM B。在 TVM B 的应力降解研究中，制备了四种 DPs（DPs 1-4），并通过 MS 和 NMR 对其进行了表征。其中，DP 2 和 DP 3 以前从未报道过。此外，还对这些 DPs 的杀线虫活性进行了评估。

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Crystal structure and the degradation products of Tenvermectin B.

The purpose of this work was to investigate the crystal structure and degradant products (DPs) of tenvermectin B (TVM B). A suitable crystal of TVM B was obtained from a solvent system (MeOH:formamide:H₂O = 2:5:2) and its absolute configuration was unambiguously established by single-crystal X-ray diffraction analysis. Meanwhile, a formamide-assisted crystallisation method for the purification of TVM B was developed. During the stress degradation studies of TVM B, four DPs (DPs 1-4) were prepared and characterised by MS and NMR. Among them, DP 2 and DP 3 have not been reported previously. In addition, the nematocidal activity of these DPs were evaluated.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.