非小细胞肺癌患者接受新辅助免疫疗法后的辅助治疗

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES iScience Pub Date : 2024-10-28 DOI:10.1016/j.isci.2024.111281

Junfeng Zhao , Ying Li , Ruyue Li , Xiujing Yao , Xue Dong , Lin Su , Yintao Li

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引用次数: 0

摘要

这项研究探讨了在NICT和手术后进行辅助免疫疗法的可行性。这项回顾性研究针对接受了 NICT 和手术的 NSCLC 患者。根据NICT和手术后的辅助治疗情况将患者分为两组：化疗组（单纯化疗）和免疫+化疗组（化疗联合免疫治疗）。此外，还对无病生存期（DFS）和总生存期（OS）进行了分析。共有 209 名患者入组。免疫+化疗组和化疗组的中位无病生存期分别为 26 个月（危险比 [HR]：0.498，95% 置信区间 [CI]：0.315-0.787, p = 0.002).此外，还观察到 OS 方面的明显差异；不过，两组患者均未达到中位 OS（HR：0.526，95% CI：0.287-0.965，P = 0.034）。在接受NICT和手术治疗的NSCLC患者中，术后辅助化疗联合免疫疗法的疗效明显优于单纯辅助化疗。

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Adjuvant treatment after neoadjuvant immunotherapy in patients with non-small cell lung cancer

This study explored the feasibility of adjuvant immunotherapy after NICT and surgery. A retrospective study was conducted on NSCLC patients who underwent NICT and surgery. Two patient groups were defined based on their adjuvant therapy after NICT and surgery: the Chemo group (chemotherapy alone) and the Immuno+Chemo group (chemotherapy combined with immunotherapy). Disease-free survival (DFS) and overall survival (OS) were also analyzed. In total, 209 patients were enrolled. The median DFS for the Immuno+Chemo group and the Chemo group was not reached vs. 26 months (hazard ratio [HR]: 0.498, 95% confidence interval [CI]: 0.315–0.787, p = 0.002). A significant difference in OS was also observed; however, the median OS was not reached in either group (HR: 0.526, 95% CI: 0.287–0.965, p = 0.034). Postoperative adjuvant chemotherapy combined with immunotherapy was significantly more effective than adjuvant chemotherapy alone in patients with NSCLC treated with NICT and surgery.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

期刊介绍： Science has many big remaining questions. To address them, we will need to work collaboratively and across disciplines. The goal of iScience is to help fuel that type of interdisciplinary thinking. iScience is a new open-access journal from Cell Press that provides a platform for original research in the life, physical, and earth sciences. The primary criterion for publication in iScience is a significant contribution to a relevant field combined with robust results and underlying methodology. The advances appearing in iScience include both fundamental and applied investigations across this interdisciplinary range of topic areas. To support transparency in scientific investigation, we are happy to consider replication studies and papers that describe negative results. We know you want your work to be published quickly and to be widely visible within your community and beyond. With the strong international reputation of Cell Press behind it, publication in iScience will help your work garner the attention and recognition it merits. Like all Cell Press journals, iScience prioritizes rapid publication. Our editorial team pays special attention to high-quality author service and to efficient, clear-cut decisions based on the information available within the manuscript. iScience taps into the expertise across Cell Press journals and selected partners to inform our editorial decisions and help publish your science in a timely and seamless way.