Sergei A. Chernenko , Anton L. Shatsauskas , Yuri V. Shatalin , Victoria S. Shubina , Margarita I. Kobyakova , Tatyana Yu Zheleznova , Anastasia S. Kostyuchenko , Alexander S. Fisyuk
{"title":"1-烷基氨基-3H-萘并[1,2,3-de]喹啉-2,7-二酮。活细胞中脂滴的可视化","authors":"Sergei A. Chernenko , Anton L. Shatsauskas , Yuri V. Shatalin , Victoria S. Shubina , Margarita I. Kobyakova , Tatyana Yu Zheleznova , Anastasia S. Kostyuchenko , Alexander S. Fisyuk","doi":"10.1016/j.dyepig.2024.112541","DOIUrl":null,"url":null,"abstract":"<div><div>A series of previously unknown 1-alkylamino-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-diones, 1-alkylamino-6-nitro-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-diones, and 1-alkylamino-6-amino-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-diones was obtained by nucleophilic substitution of the tosyl group of 1-tosyl-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-dione with aliphatic amines. Among the synthesized compounds, fluorophores emitting light from the blue-green to orange-red region of the visible spectrum with fluorescence quantum yields up to 0.39 were found. Some of the synthesized compounds showed phototoxic effects on human breast carcinoma cell line BT474. It was shown that 3-butyl-1-(butylamino)-6-nitronaphthoquinolinedione stains exclusively lipid droplets, has a large Stokes shift and can be used for visualization of these organelles.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"233 ","pages":"Article 112541"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"1-Alkylamino-3H-naphtho[1,2,3-de]quinoline-2,7-diones. Visualization of lipid droplets in living cells\",\"authors\":\"Sergei A. Chernenko , Anton L. Shatsauskas , Yuri V. Shatalin , Victoria S. Shubina , Margarita I. Kobyakova , Tatyana Yu Zheleznova , Anastasia S. Kostyuchenko , Alexander S. Fisyuk\",\"doi\":\"10.1016/j.dyepig.2024.112541\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A series of previously unknown 1-alkylamino-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-diones, 1-alkylamino-6-nitro-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-diones, and 1-alkylamino-6-amino-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-diones was obtained by nucleophilic substitution of the tosyl group of 1-tosyl-3<em>H</em>-naphtho[1,2,3-<em>de</em>]quinoline-2,7-dione with aliphatic amines. Among the synthesized compounds, fluorophores emitting light from the blue-green to orange-red region of the visible spectrum with fluorescence quantum yields up to 0.39 were found. Some of the synthesized compounds showed phototoxic effects on human breast carcinoma cell line BT474. It was shown that 3-butyl-1-(butylamino)-6-nitronaphthoquinolinedione stains exclusively lipid droplets, has a large Stokes shift and can be used for visualization of these organelles.</div></div>\",\"PeriodicalId\":302,\"journal\":{\"name\":\"Dyes and Pigments\",\"volume\":\"233 \",\"pages\":\"Article 112541\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dyes and Pigments\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0143720824006077\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dyes and Pigments","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143720824006077","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
1-Alkylamino-3H-naphtho[1,2,3-de]quinoline-2,7-diones. Visualization of lipid droplets in living cells
A series of previously unknown 1-alkylamino-3H-naphtho[1,2,3-de]quinoline-2,7-diones, 1-alkylamino-6-nitro-3H-naphtho[1,2,3-de]quinoline-2,7-diones, and 1-alkylamino-6-amino-3H-naphtho[1,2,3-de]quinoline-2,7-diones was obtained by nucleophilic substitution of the tosyl group of 1-tosyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione with aliphatic amines. Among the synthesized compounds, fluorophores emitting light from the blue-green to orange-red region of the visible spectrum with fluorescence quantum yields up to 0.39 were found. Some of the synthesized compounds showed phototoxic effects on human breast carcinoma cell line BT474. It was shown that 3-butyl-1-(butylamino)-6-nitronaphthoquinolinedione stains exclusively lipid droplets, has a large Stokes shift and can be used for visualization of these organelles.
期刊介绍：
Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied.
Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media.
The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
