莱姆病中念珠菌和鲍氏菌联合生物膜的重要性以及超声波治疗的价值:医学假说

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Medical hypotheses Pub Date : 2024-11-12 DOI:10.1016/j.mehy.2024.111522
Jean-Pierre Tournier , Pierre-Yves Marcy , Christian Perronne , Alexis Lacout
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引用次数: 0

摘要

莱姆病的慢性形式正得到亚特兰大疾病预防控制中心的普遍认可。众所周知,生物膜是许多感染持续存在的关键因素,因此,生物膜可能是导致疾病进一步慢性化的原因。细菌在人类宿主体内持续存在的其他机制可能涉及生态系统以及鲍瑞氏菌与周围微生物(如念珠菌)相互作用的能力。此外,念珠菌病可能是通过产生霉菌毒素而导致类似莱姆病的临床综合征的根源。除了抗生素治疗外,我们还假设慢性莱姆病的治疗可以包括使用抗真菌药物。评估能破坏生物膜的药物似乎也很重要。一种非常规的新方法是在传统疗法的基础上增加机械工具,通过使用低频超声波来破坏这些生物膜。
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The importance of combined Candida & Borrelia biofilms in Lyme’s disease and the value of ultrasound treatment: A medical hypothesis
The chronic form of Lyme’s disease is gaining general recognition by the CDC in Atlanta.
The factors contributing to the chronicity of this disease are well-documented in the current literature. Biofilms are known being key-factors for the persistence of many infections and thus may explain the passage to further disease’s chronicity. Other mechanisms of bacteria’s persistence into the human host may involve the ecosystem and the Borrelia’s ability to interact with the surrounding microorganisms, like Candida. Moreover, candidiasis could be at the origin of clinical syndromes resembling Lyme’s disease, via the production of mycotoxins. In addition to antibiotic therapy, we hypothesize that the treatment of chronic Lyme’s disease could include the administration of antifungal drugs. It also seems important to evaluate the drugs that could destroy biofilms. An unconventional and original approach could be to add to the conventional therapy mechanical tools to destroying these biofilms by using low-frequency ultrasound.
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来源期刊
Medical hypotheses
Medical hypotheses 医学-医学:研究与实验
CiteScore
10.60
自引率
2.10%
发文量
167
审稿时长
60 days
期刊介绍: Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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