{"title":"莱姆病中念珠菌和鲍氏菌联合生物膜的重要性以及超声波治疗的价值:医学假说","authors":"Jean-Pierre Tournier , Pierre-Yves Marcy , Christian Perronne , Alexis Lacout","doi":"10.1016/j.mehy.2024.111522","DOIUrl":null,"url":null,"abstract":"<div><div>The chronic form of Lyme’s disease is gaining<!--> <!-->general recognition by the CDC in Atlanta.</div><div>The factors contributing to the chronicity of this disease are well-documented in the current literature. Biofilms are known being key-factors for the persistence of many infections and thus may explain the passage to further disease’s chronicity. Other mechanisms of bacteria’s persistence into the human host may involve the ecosystem and the <em>Borrelia</em>’s ability to interact with the surrounding microorganisms, like <em>Candida.</em> Moreover, candidiasis could be at the origin of clinical syndromes resembling Lyme’s disease, via the production of mycotoxins. In addition to antibiotic therapy, we hypothesize that the treatment of chronic Lyme’s disease could include the administration of antifungal drugs. It also seems important to evaluate the drugs that could destroy biofilms. An unconventional and original approach could be to add to the conventional therapy mechanical tools to destroying these biofilms by using low-frequency ultrasound.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"194 ","pages":"Article 111522"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The importance of combined Candida & Borrelia biofilms in Lyme’s disease and the value of ultrasound treatment: A medical hypothesis\",\"authors\":\"Jean-Pierre Tournier , Pierre-Yves Marcy , Christian Perronne , Alexis Lacout\",\"doi\":\"10.1016/j.mehy.2024.111522\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The chronic form of Lyme’s disease is gaining<!--> <!-->general recognition by the CDC in Atlanta.</div><div>The factors contributing to the chronicity of this disease are well-documented in the current literature. Biofilms are known being key-factors for the persistence of many infections and thus may explain the passage to further disease’s chronicity. Other mechanisms of bacteria’s persistence into the human host may involve the ecosystem and the <em>Borrelia</em>’s ability to interact with the surrounding microorganisms, like <em>Candida.</em> Moreover, candidiasis could be at the origin of clinical syndromes resembling Lyme’s disease, via the production of mycotoxins. In addition to antibiotic therapy, we hypothesize that the treatment of chronic Lyme’s disease could include the administration of antifungal drugs. It also seems important to evaluate the drugs that could destroy biofilms. An unconventional and original approach could be to add to the conventional therapy mechanical tools to destroying these biofilms by using low-frequency ultrasound.</div></div>\",\"PeriodicalId\":18425,\"journal\":{\"name\":\"Medical hypotheses\",\"volume\":\"194 \",\"pages\":\"Article 111522\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical hypotheses\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306987724002652\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724002652","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
The importance of combined Candida & Borrelia biofilms in Lyme’s disease and the value of ultrasound treatment: A medical hypothesis
The chronic form of Lyme’s disease is gaining general recognition by the CDC in Atlanta.
The factors contributing to the chronicity of this disease are well-documented in the current literature. Biofilms are known being key-factors for the persistence of many infections and thus may explain the passage to further disease’s chronicity. Other mechanisms of bacteria’s persistence into the human host may involve the ecosystem and the Borrelia’s ability to interact with the surrounding microorganisms, like Candida. Moreover, candidiasis could be at the origin of clinical syndromes resembling Lyme’s disease, via the production of mycotoxins. In addition to antibiotic therapy, we hypothesize that the treatment of chronic Lyme’s disease could include the administration of antifungal drugs. It also seems important to evaluate the drugs that could destroy biofilms. An unconventional and original approach could be to add to the conventional therapy mechanical tools to destroying these biofilms by using low-frequency ultrasound.
期刊介绍:
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.