Tiago Carvalho , Jackson Cunha , Rodrigo Euzébio , Marco Florentino
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引用次数: 0
摘要
在本文中,我们研究了一个片断平滑矢量场的动力学模型,它模拟了一种间歇性人类免疫缺陷病毒治疗方法,在这种治疗方法中,病人会反复服药和停药。事实上,治疗方案规定,当 CD4+ T 防御细胞的水平小于一个固定的数字 CoffT 时,就会给药。当 CD4+ T 细胞的水平大于一个固定的数字 ConT(与 CoffT 不同)时,则不用药,以便更好地从副作用中恢复过来。此外,片断平滑矢量场的轨道被困在一个紧凑集合内,这证明该方案能控制疾病。
Dynamics of an intermittent HIV treatment using piecewise smooth vector fields with two switching manifolds
In this paper we study the dynamics of a piecewise smooth vector field modeling an intermittent human immunodeficiency virus treatment where the patient is recurrently submitted and removed from drug administration. In fact, the protocol says that the drugs are administered when the level of CD4 T defense cells is smaller than a fixed number . When the level of CD4 T cells is greater than a fixed number (distinct from ) the drugs are not administered to provide a better recovery from side effects. Moreover, the orbits of the piecewise smooth vector fields are trapped within a compact set, which proves that the protocol controls the disease.
期刊介绍:
Nonlinear Analysis: Real World Applications welcomes all research articles of the highest quality with special emphasis on applying techniques of nonlinear analysis to model and to treat nonlinear phenomena with which nature confronts us. Coverage of applications includes any branch of science and technology such as solid and fluid mechanics, material science, mathematical biology and chemistry, control theory, and inverse problems.
The aim of Nonlinear Analysis: Real World Applications is to publish articles which are predominantly devoted to employing methods and techniques from analysis, including partial differential equations, functional analysis, dynamical systems and evolution equations, calculus of variations, and bifurcations theory.