{"title":"抗类风湿关节炎药物的金纳米颗粒给药系统的合成与生物学评价","authors":"Jiahui Fan , Xuena Li , Meizi Jin , Cheng Li","doi":"10.1016/j.jddst.2024.106402","DOIUrl":null,"url":null,"abstract":"<div><div>The gold nanoparticle-cysteine-methotrexate (GNPs-Cys-MTX) drug delivery system was developed for the passive targeted therapy of rheumatoid arthritis (RA) to enhance drug delivery efficiency while minimizing toxicity and side effects. The preparation and characterization of the GNPs-Cys-MTX drug delivery system were successfully achieved using Cys as a coupling agent. An IL-1β-induced anti-inflammatory study of rheumatoid arthritis fibroblast synoviocytes (RA-FLSs) demonstrated that GNPs-Cys-MTX exhibited dose-dependent anti-inflammatory effects and effectively inhibited the expression of TNF-α, IL-6, and IL-17. Furthermore, studies involving collagen-induced arthritis rats revealed that GNPs-Cys-MTX demonstrated superior therapeutic efficacy compared to free MTX, even at the same drug dose. In summary, this study demonstrates that the GNPs-Cys-MTX drug delivery system can enhance drug efficacy while reducing toxicity and side effects in the treatment of RA.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"102 ","pages":"Article 106402"},"PeriodicalIF":4.5000,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and biological evaluation of gold nanoparticles drug delivery system for anti-rheumatoid arthritis agents\",\"authors\":\"Jiahui Fan , Xuena Li , Meizi Jin , Cheng Li\",\"doi\":\"10.1016/j.jddst.2024.106402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The gold nanoparticle-cysteine-methotrexate (GNPs-Cys-MTX) drug delivery system was developed for the passive targeted therapy of rheumatoid arthritis (RA) to enhance drug delivery efficiency while minimizing toxicity and side effects. The preparation and characterization of the GNPs-Cys-MTX drug delivery system were successfully achieved using Cys as a coupling agent. An IL-1β-induced anti-inflammatory study of rheumatoid arthritis fibroblast synoviocytes (RA-FLSs) demonstrated that GNPs-Cys-MTX exhibited dose-dependent anti-inflammatory effects and effectively inhibited the expression of TNF-α, IL-6, and IL-17. Furthermore, studies involving collagen-induced arthritis rats revealed that GNPs-Cys-MTX demonstrated superior therapeutic efficacy compared to free MTX, even at the same drug dose. In summary, this study demonstrates that the GNPs-Cys-MTX drug delivery system can enhance drug efficacy while reducing toxicity and side effects in the treatment of RA.</div></div>\",\"PeriodicalId\":15600,\"journal\":{\"name\":\"Journal of Drug Delivery Science and Technology\",\"volume\":\"102 \",\"pages\":\"Article 106402\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-11-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug Delivery Science and Technology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1773224724010712\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Delivery Science and Technology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1773224724010712","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Synthesis and biological evaluation of gold nanoparticles drug delivery system for anti-rheumatoid arthritis agents
The gold nanoparticle-cysteine-methotrexate (GNPs-Cys-MTX) drug delivery system was developed for the passive targeted therapy of rheumatoid arthritis (RA) to enhance drug delivery efficiency while minimizing toxicity and side effects. The preparation and characterization of the GNPs-Cys-MTX drug delivery system were successfully achieved using Cys as a coupling agent. An IL-1β-induced anti-inflammatory study of rheumatoid arthritis fibroblast synoviocytes (RA-FLSs) demonstrated that GNPs-Cys-MTX exhibited dose-dependent anti-inflammatory effects and effectively inhibited the expression of TNF-α, IL-6, and IL-17. Furthermore, studies involving collagen-induced arthritis rats revealed that GNPs-Cys-MTX demonstrated superior therapeutic efficacy compared to free MTX, even at the same drug dose. In summary, this study demonstrates that the GNPs-Cys-MTX drug delivery system can enhance drug efficacy while reducing toxicity and side effects in the treatment of RA.
期刊介绍：
The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.
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