比较荨麻和安慰剂对绝经后妇女阴道细胞学和 pH 值的影响:随机对照试验

IF 2.2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Herbal Medicine Pub Date : 2024-11-13 DOI:10.1016/j.hermed.2024.100964
Nahid Nazari , Fatemeh Zahra Karimi , Hassan Rakhshandeh , Seyed Reza Mazloom , Ramin Azarhoush
{"title":"比较荨麻和安慰剂对绝经后妇女阴道细胞学和 pH 值的影响:随机对照试验","authors":"Nahid Nazari ,&nbsp;Fatemeh Zahra Karimi ,&nbsp;Hassan Rakhshandeh ,&nbsp;Seyed Reza Mazloom ,&nbsp;Ramin Azarhoush","doi":"10.1016/j.hermed.2024.100964","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Decreased estrogen in the period of menopause causes thinning of the vaginal lining, a rise in vaginal acidity, and a drop in vaginal maturation levels. Menopausal women are seeking treatment for bothersome vaginal symptoms, opting for herbal treatments instead of hormone therapy due to their side effects or contraindications.</div></div><div><h3>Methods</h3><div>In 2021–2022, a triple-blind randomized placebo-controlled clinical trial was carried out on 84 postmenopausal women aged 45–60 from Golestan who had the eligibility criteria and sought services from comprehensive health centers. The qualified females were given 5% vaginal cream containing Urtica dioica extract and a placebo for a duration of 8 weeks. Analysis of data was performed with SPSS. Vaginal PH and maturation value were measured before, as well as four and eight weeks following the intervention.</div></div><div><h3>Results</h3><div>Before the intervention, there was no significant difference in the mean (SD) scores of the vaginal pH and VMV between the two groups. During the fourth and eighth weeks post-intervention in the Urtica dioica group, the mean (SD) vaginal pH scores were 4.8 ± 0.7 and 4.3 ± 1.0, and also the mean (SD) VMV scores were 50.8 ± 8.8 and 51.3 ± 8.9, respectively. There was a significant difference between the intervention group and the placebo group (P&lt;0.001).</div></div><div><h3>Conclusions</h3><div>After using Urtica dioica vaginal cream for eight weeks, postmenopausal women displayed higher vaginal maturation value and lower vaginal pH.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial\",\"authors\":\"Nahid Nazari ,&nbsp;Fatemeh Zahra Karimi ,&nbsp;Hassan Rakhshandeh ,&nbsp;Seyed Reza Mazloom ,&nbsp;Ramin Azarhoush\",\"doi\":\"10.1016/j.hermed.2024.100964\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Decreased estrogen in the period of menopause causes thinning of the vaginal lining, a rise in vaginal acidity, and a drop in vaginal maturation levels. Menopausal women are seeking treatment for bothersome vaginal symptoms, opting for herbal treatments instead of hormone therapy due to their side effects or contraindications.</div></div><div><h3>Methods</h3><div>In 2021–2022, a triple-blind randomized placebo-controlled clinical trial was carried out on 84 postmenopausal women aged 45–60 from Golestan who had the eligibility criteria and sought services from comprehensive health centers. The qualified females were given 5% vaginal cream containing Urtica dioica extract and a placebo for a duration of 8 weeks. Analysis of data was performed with SPSS. Vaginal PH and maturation value were measured before, as well as four and eight weeks following the intervention.</div></div><div><h3>Results</h3><div>Before the intervention, there was no significant difference in the mean (SD) scores of the vaginal pH and VMV between the two groups. During the fourth and eighth weeks post-intervention in the Urtica dioica group, the mean (SD) vaginal pH scores were 4.8 ± 0.7 and 4.3 ± 1.0, and also the mean (SD) VMV scores were 50.8 ± 8.8 and 51.3 ± 8.9, respectively. There was a significant difference between the intervention group and the placebo group (P&lt;0.001).</div></div><div><h3>Conclusions</h3><div>After using Urtica dioica vaginal cream for eight weeks, postmenopausal women displayed higher vaginal maturation value and lower vaginal pH.</div></div>\",\"PeriodicalId\":56077,\"journal\":{\"name\":\"Journal of Herbal Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Herbal Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210803324001210\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210803324001210","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial

Introduction

Decreased estrogen in the period of menopause causes thinning of the vaginal lining, a rise in vaginal acidity, and a drop in vaginal maturation levels. Menopausal women are seeking treatment for bothersome vaginal symptoms, opting for herbal treatments instead of hormone therapy due to their side effects or contraindications.

Methods

In 2021–2022, a triple-blind randomized placebo-controlled clinical trial was carried out on 84 postmenopausal women aged 45–60 from Golestan who had the eligibility criteria and sought services from comprehensive health centers. The qualified females were given 5% vaginal cream containing Urtica dioica extract and a placebo for a duration of 8 weeks. Analysis of data was performed with SPSS. Vaginal PH and maturation value were measured before, as well as four and eight weeks following the intervention.

Results

Before the intervention, there was no significant difference in the mean (SD) scores of the vaginal pH and VMV between the two groups. During the fourth and eighth weeks post-intervention in the Urtica dioica group, the mean (SD) vaginal pH scores were 4.8 ± 0.7 and 4.3 ± 1.0, and also the mean (SD) VMV scores were 50.8 ± 8.8 and 51.3 ± 8.9, respectively. There was a significant difference between the intervention group and the placebo group (P<0.001).

Conclusions

After using Urtica dioica vaginal cream for eight weeks, postmenopausal women displayed higher vaginal maturation value and lower vaginal pH.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Herbal Medicine
Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.90
自引率
0.00%
发文量
94
期刊介绍: The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.
期刊最新文献
Evaluating efficacy and safety of Saffron add-on treatment in improvement of motor and depressive symptoms of patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled clinical trial Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial Phytochemical examination of Cistus laurifolius extract and its impact on cytotoxicity, apoptosis and oxidative stress in colorectal and breast cancer cell lines Traditional use of medicinal plants in Brazil to treat mycosis, antifungal activity, and their nanomaterials against Trichophyton rubrum Chinese Herbal Bath for Eczema: A Systematic Review and Meta-analysis of 39 Randomised Controlled Trials
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1