Zao-Yu Xu , Chao-Fan Wang , Wen Li , Nan Fu , Rui Zhan
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Alkaloids from Dendrobium nobile and their anti-inflammatory activities
To identify anti-inflammatory alkaloids, we investigated the aerial parts of cultivated Dendrobium nobile Lindl. Thirteen alkaloids, including a new one, were isolated from the chloroform extract, and their structures were determined using spectroscopic methods. Bioassays assessed the anti-inflammatory activities of these isolates. Compounds 1 and 9 demonstrated inhibition of nitric oxide production in LPS-activated RAW264.7 macrophages, with IC50 values of 16.7 μM and 24.4 μM, respectively.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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