{"title":"具有抗癌活性的 Piptoporellus baudonii（Fomitopsidaceae）中的两种糙二丁二聚体","authors":"Jenifer Reine Ngnouzouba Kuete , Olyvia Gwladys Fadeyi , Boris Armel Olou , Frank Wilson Tiatsop Kenmoe , Bienvenu Tsakem , Rémy Bertrand Teponno , Léon Azefack Tapondjou , Simeon Fogue Kouam , Nourou Soulemane Yorou","doi":"10.1016/j.phytol.2024.11.002","DOIUrl":null,"url":null,"abstract":"<div><div>Chemical analysis of the ethanol extract from the stromata of <em>Piptoporellus baudonii</em> led to the isolation and characterization of two unreported bishispidin derivatives named 11-hydroxysquarrosidine (<strong>1</strong>) and laetipohispidin (<strong>2</strong>) together with two known terpenoids: ergosterol (<strong>3</strong>) and eburicoic acid (<strong>4</strong>). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR, UV, IR, ECD as well as the high-resolution mass spectrometry. Although metabolite <strong>1</strong> was reported in a patent as a synthetic compound, this is the first report on its isolation from natural source. Compounds <strong>1</strong> and <strong>2</strong> were evaluated for their antimicrobial and cytotoxic activities. 11-hydroxysquarrosidine (<strong>1</strong>) exhibited a moderate activity against all the tested human cancer cell lines with IC<sub>50</sub> values ranging from 25.79 to 73.41 µM.</div></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"65 ","pages":"Pages 19-23"},"PeriodicalIF":1.3000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two hispidin dimers from Piptoporellus baudonii (Fomitopsidaceae) with anticancer activity\",\"authors\":\"Jenifer Reine Ngnouzouba Kuete , Olyvia Gwladys Fadeyi , Boris Armel Olou , Frank Wilson Tiatsop Kenmoe , Bienvenu Tsakem , Rémy Bertrand Teponno , Léon Azefack Tapondjou , Simeon Fogue Kouam , Nourou Soulemane Yorou\",\"doi\":\"10.1016/j.phytol.2024.11.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Chemical analysis of the ethanol extract from the stromata of <em>Piptoporellus baudonii</em> led to the isolation and characterization of two unreported bishispidin derivatives named 11-hydroxysquarrosidine (<strong>1</strong>) and laetipohispidin (<strong>2</strong>) together with two known terpenoids: ergosterol (<strong>3</strong>) and eburicoic acid (<strong>4</strong>). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR, UV, IR, ECD as well as the high-resolution mass spectrometry. Although metabolite <strong>1</strong> was reported in a patent as a synthetic compound, this is the first report on its isolation from natural source. Compounds <strong>1</strong> and <strong>2</strong> were evaluated for their antimicrobial and cytotoxic activities. 11-hydroxysquarrosidine (<strong>1</strong>) exhibited a moderate activity against all the tested human cancer cell lines with IC<sub>50</sub> values ranging from 25.79 to 73.41 µM.</div></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"65 \",\"pages\":\"Pages 19-23\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390024001472\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001472","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Two hispidin dimers from Piptoporellus baudonii (Fomitopsidaceae) with anticancer activity
Chemical analysis of the ethanol extract from the stromata of Piptoporellus baudonii led to the isolation and characterization of two unreported bishispidin derivatives named 11-hydroxysquarrosidine (1) and laetipohispidin (2) together with two known terpenoids: ergosterol (3) and eburicoic acid (4). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR, UV, IR, ECD as well as the high-resolution mass spectrometry. Although metabolite 1 was reported in a patent as a synthetic compound, this is the first report on its isolation from natural source. Compounds 1 and 2 were evaluated for their antimicrobial and cytotoxic activities. 11-hydroxysquarrosidine (1) exhibited a moderate activity against all the tested human cancer cell lines with IC50 values ranging from 25.79 to 73.41 µM.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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