封面：Pd-Monothiosquaramides：Pd-Monothiosquaramides: Efficient Catalysts for the Enantioselective Imine Reduction of Dihydro-β-Carbolines (Asian J. Org. Chem. 11/2024)

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-11-16 DOI:10.1002/ajoc.202481101

Francisco A. A. Reis, Dr. Manda Sathish, Jorge Villaseñor, Dr. Fabiane M. Nachtigall, Dr. Leonardo S. Santos

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摘要

研究人员尝试利用原位生成的手性钯单硫代奎拉姆（Pd-MTSQs）高效地对映体选择性合成四氢-β-羰基化合物。Pd-MTSQs 催化了二氢-β-咔啉的亚胺还原反应，并以极佳的选择性（高达 98% ee）生成了手性 THBC。观察到手性烷基-THBC 异构体具有手性芳基-THBC 的 R 构型和 S 构型。更多详细信息，请参阅 Nachtigall、Leonardo S. Santos 及合作者发表的 e202400245 号文章。

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Front Cover: Pd-Monothiosquaramides: Efficient Catalysts for the Enantioselective Imine Reduction of Dihydro-β-Carbolines (Asian J. Org. Chem. 11/2024)

An efficient enantioselective synthesis of tetrahydro-β-carbolines using in situ generated chiral Pd-monothiosquaramides (Pd-MTSQs) was attempted. The Pd-MTSQs catalyzed imine reduction of dihydro-β-carbolines and produced chiral THBCs with excellent selectivity (up to 98% ee). Chiral alkyl-THBC isomers were observed with R configuration and S configuration perceived for chiral Aryl-THBCs. More details can be found in article number e202400245 by Nachtigall, Leonardo S. Santos, and co-workers.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.