{"title":"利用稳定自由基作为 \"电子供体\"，开发用于高效 I 型光动力疗法的自由基光敏剂。","authors":"Xiao Cui, Fang Fang, Huan Chen, Chen Cao, Yafang Xiao, Shuang Tian, Jinfeng Zhang, Shengliang Li, Chun-Sing Lee","doi":"10.1039/d4mh00952e","DOIUrl":null,"url":null,"abstract":"<p><p>Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available \"TEMPO\" moiety. The radical exhibits efficient type-I ROS generation and appreciable photo-cytotoxicity under hypoxia, which open up a new avenue for the exploration of a novel and efficient type-I photosensitizer.</p>","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Using a stable radical as an \\\"electron donor\\\" to develop a radical photosensitizer for efficient type-I photodynamic therapy.\",\"authors\":\"Xiao Cui, Fang Fang, Huan Chen, Chen Cao, Yafang Xiao, Shuang Tian, Jinfeng Zhang, Shengliang Li, Chun-Sing Lee\",\"doi\":\"10.1039/d4mh00952e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available \\\"TEMPO\\\" moiety. The radical exhibits efficient type-I ROS generation and appreciable photo-cytotoxicity under hypoxia, which open up a new avenue for the exploration of a novel and efficient type-I photosensitizer.</p>\",\"PeriodicalId\":87,\"journal\":{\"name\":\"Materials Horizons\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":12.2000,\"publicationDate\":\"2024-11-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Horizons\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1039/d4mh00952e\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Horizons","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1039/d4mh00952e","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
在 I 型光敏剂中，稳定的有机自由基是克服缺氧的光动力疗法的理想候选分子。然而，复杂的制备过程和较差的稳定性限制了它们的广泛应用。在此，我们通过引入市售的 "TEMPO "分子，简单地合成了一种亚硝基自由基。该自由基在缺氧条件下具有高效的 I 型 ROS 生成能力和明显的光毒性，为探索新型高效 I 型光敏剂开辟了一条新途径。
Using a stable radical as an "electron donor" to develop a radical photosensitizer for efficient type-I photodynamic therapy.
Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available "TEMPO" moiety. The radical exhibits efficient type-I ROS generation and appreciable photo-cytotoxicity under hypoxia, which open up a new avenue for the exploration of a novel and efficient type-I photosensitizer.
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