奥曲肽：首次批准。

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY Drugs Pub Date : 2024-11-19 DOI:10.1007/s40265-024-02112-6

Hannah A Blair

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引用次数: 0

摘要

Odronextamab（Ordspono™）是一种 CD20xCD3 双特异性抗体，由 Regeneron 制药公司开发，用于治疗 B 细胞非霍奇金淋巴瘤。2024 年 8 月 26 日，odronextamab 首次获得欧盟批准，作为单一疗法用于治疗复发/难治性滤泡性淋巴瘤（FL）或经≥ 2 线系统治疗后复发/难治性弥漫大 B 细胞淋巴瘤（DLBCL）成人患者。针对其他各种 B 细胞非霍奇金淋巴瘤（包括套细胞淋巴瘤、边缘区淋巴瘤和慢性淋巴细胞白血病）的临床试验正在多个国家进行。本文总结了odronextamab开发过程中的里程碑事件，这些事件促成了odronextamab首次被批准用于治疗复发/难治性FL或复发/难治性DLBCL成人患者。

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Odronextamab: First Approval.

Odronextamab (Ordspono^™), a CD20xCD3 bispecific antibody, is being developed by Regeneron Pharmaceuticals for the treatment of B-cell non-Hodgkin's lymphoma. On 26 August 2024, odronextamab received its first approval in the EU as monotherapy for the treatment of adult patients with relapsed/refractory follicular lymphoma (FL) or relapsed/refractory diffuse large B-cell lymphoma (DLBCL) after ≥ 2 lines of systemic therapy. Clinical trials in various other B-cell non-Hodgkin's lymphoma, including mantle cell lymphoma, marginal zone lymphoma and chronic lymphocytic leukaemia, are underway in multiple countries. This article summarizes the milestones in the development of odronextamab leading to this first approval for the treatment of adult patients with relapsed/refractory FL or relapsed/refractory DLBCL.

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.

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