{"title":"比较雾化或滴鼻阿替帕米唑与肌肉注射阿替帕米唑对健康狗逆转美托咪定镇静作用的效果。","authors":"Majid Jafarbeglou DVM, DVSc, Mehdi Marjani DVM, DVSc, Mohammadreza Oghbaei DVM, Mohammadreza Paryani DVM, PhD, Reza Bakhshi-Khanghah DVM","doi":"10.1111/vec.13439","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To determine and compare the efficacy of intranasal (IN) atomization, IN drops, and IM injection of atipamezole for reversal of medetomidine-induced sedation in healthy dogs.</p>\n </section>\n \n <section>\n \n <h3> Design</h3>\n \n <p>Prospective, randomized, blinded study.</p>\n </section>\n \n <section>\n \n <h3> Setting</h3>\n \n <p>University teaching hospital.</p>\n </section>\n \n <section>\n \n <h3> Animals</h3>\n \n <p>Forty mixed-breed, shelter-owned dogs with an average weight of 29.9 ± 5.6 kg (mean ± SD) that required sedation for minor diagnostic or therapeutic procedures.</p>\n </section>\n \n <section>\n \n <h3> Interventions</h3>\n \n <p>Atipamezole was administered by a dog handler at 200 µg/kg via IN atomization (ATI-IN<sub>A</sub>, <i>n</i> = 10), IN drops (ATI-IN<sub>D</sub>, <i>n</i> = 10), or IM injection (ATI-IM, <i>n</i> = 10) 20 minutes following medetomidine administration (40 µg/kg). A control group (<i>n</i> = 10) received no atipamezole.</p>\n </section>\n \n <section>\n \n <h3> Measurements and Main Results</h3>\n \n <p>Ease of atipamezole administration was evaluated. Sedation score, heart rate (HR), respiratory rate (RR), and blood pressure (BP) were recorded pre-medetomidine administration (T0), pre-atipamezole administration (T20), and at multiple intervals following atipamezole administration. ATI-IM resulted in the fastest recovery, followed by ATI-IN<sub>A</sub>, with ATI-IN<sub>D</sub> being the slowest. The adverse cardiovascular impacts of medetomidine were not completely mitigated. ATI-IM showed initial HR restoration followed by a decline. HR in both IN groups showed a slower increase compared to ATI-IM, but no subsequent decline was observed. ATI-IM resulted in a transient decrease in BP, though dogs remained normotensive. A gradual reduction in BP was noted in the IN groups. At T50, RR of all atipamezole groups differed from control, and a significant increase in RR was observed in ATI-IM dogs compared to pre-atipamezole value. No adverse effects were observed.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>All routes for atipamezole administration effectively reversed medetomidine-induced sedation, with ATI-IM being fastest. IN routes were easy for the dog handler to administer, making them viable alternatives in cases of accidental drug exposure, particularly outside a hospital setting.</p>\n </section>\n </div>","PeriodicalId":17603,"journal":{"name":"Journal of veterinary emergency and critical care","volume":"34 6","pages":"530-538"},"PeriodicalIF":1.1000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs\",\"authors\":\"Majid Jafarbeglou DVM, DVSc, Mehdi Marjani DVM, DVSc, Mohammadreza Oghbaei DVM, Mohammadreza Paryani DVM, PhD, Reza Bakhshi-Khanghah DVM\",\"doi\":\"10.1111/vec.13439\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To determine and compare the efficacy of intranasal (IN) atomization, IN drops, and IM injection of atipamezole for reversal of medetomidine-induced sedation in healthy dogs.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Design</h3>\\n \\n <p>Prospective, randomized, blinded study.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Setting</h3>\\n \\n <p>University teaching hospital.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Animals</h3>\\n \\n <p>Forty mixed-breed, shelter-owned dogs with an average weight of 29.9 ± 5.6 kg (mean ± SD) that required sedation for minor diagnostic or therapeutic procedures.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Interventions</h3>\\n \\n <p>Atipamezole was administered by a dog handler at 200 µg/kg via IN atomization (ATI-IN<sub>A</sub>, <i>n</i> = 10), IN drops (ATI-IN<sub>D</sub>, <i>n</i> = 10), or IM injection (ATI-IM, <i>n</i> = 10) 20 minutes following medetomidine administration (40 µg/kg). A control group (<i>n</i> = 10) received no atipamezole.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Measurements and Main Results</h3>\\n \\n <p>Ease of atipamezole administration was evaluated. Sedation score, heart rate (HR), respiratory rate (RR), and blood pressure (BP) were recorded pre-medetomidine administration (T0), pre-atipamezole administration (T20), and at multiple intervals following atipamezole administration. ATI-IM resulted in the fastest recovery, followed by ATI-IN<sub>A</sub>, with ATI-IN<sub>D</sub> being the slowest. The adverse cardiovascular impacts of medetomidine were not completely mitigated. ATI-IM showed initial HR restoration followed by a decline. HR in both IN groups showed a slower increase compared to ATI-IM, but no subsequent decline was observed. ATI-IM resulted in a transient decrease in BP, though dogs remained normotensive. A gradual reduction in BP was noted in the IN groups. At T50, RR of all atipamezole groups differed from control, and a significant increase in RR was observed in ATI-IM dogs compared to pre-atipamezole value. No adverse effects were observed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>All routes for atipamezole administration effectively reversed medetomidine-induced sedation, with ATI-IM being fastest. IN routes were easy for the dog handler to administer, making them viable alternatives in cases of accidental drug exposure, particularly outside a hospital setting.</p>\\n </section>\\n </div>\",\"PeriodicalId\":17603,\"journal\":{\"name\":\"Journal of veterinary emergency and critical care\",\"volume\":\"34 6\",\"pages\":\"530-538\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-11-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of veterinary emergency and critical care\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/vec.13439\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary emergency and critical care","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/vec.13439","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs
Objective
To determine and compare the efficacy of intranasal (IN) atomization, IN drops, and IM injection of atipamezole for reversal of medetomidine-induced sedation in healthy dogs.
Design
Prospective, randomized, blinded study.
Setting
University teaching hospital.
Animals
Forty mixed-breed, shelter-owned dogs with an average weight of 29.9 ± 5.6 kg (mean ± SD) that required sedation for minor diagnostic or therapeutic procedures.
Interventions
Atipamezole was administered by a dog handler at 200 µg/kg via IN atomization (ATI-INA, n = 10), IN drops (ATI-IND, n = 10), or IM injection (ATI-IM, n = 10) 20 minutes following medetomidine administration (40 µg/kg). A control group (n = 10) received no atipamezole.
Measurements and Main Results
Ease of atipamezole administration was evaluated. Sedation score, heart rate (HR), respiratory rate (RR), and blood pressure (BP) were recorded pre-medetomidine administration (T0), pre-atipamezole administration (T20), and at multiple intervals following atipamezole administration. ATI-IM resulted in the fastest recovery, followed by ATI-INA, with ATI-IND being the slowest. The adverse cardiovascular impacts of medetomidine were not completely mitigated. ATI-IM showed initial HR restoration followed by a decline. HR in both IN groups showed a slower increase compared to ATI-IM, but no subsequent decline was observed. ATI-IM resulted in a transient decrease in BP, though dogs remained normotensive. A gradual reduction in BP was noted in the IN groups. At T50, RR of all atipamezole groups differed from control, and a significant increase in RR was observed in ATI-IM dogs compared to pre-atipamezole value. No adverse effects were observed.
Conclusions
All routes for atipamezole administration effectively reversed medetomidine-induced sedation, with ATI-IM being fastest. IN routes were easy for the dog handler to administer, making them viable alternatives in cases of accidental drug exposure, particularly outside a hospital setting.
期刊介绍：
The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues.
The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
