推进 COVID-19 诊断：利用 30 纳米金纳米粒子内化纳米点阵基底增强 SERS-PCR (Small 46/2024)

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Small Pub Date : 2024-11-19 DOI:10.1002/smll.202470336

Hajun Dang, Younju Joung, Jun-Yeong Yang, Soo Hyun Lee, Seunghun Lee, Sang-Woo Joo, Sung-Gyu Park, Jaebum Choo

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摘要

分子诊断系统利用金纳米颗粒-金纳米微粒（AuNPs-AuNDPs）基底，Sang-Woo Joo、Sung-Gyu Park、Jaebum Choo 及其合作者在文章编号 2403672 中开发了一种高灵敏度的表面增强拉曼散射（SERS）-聚合酶链反应分子诊断测定平台，该平台能够以最少的热循环次数检测出 105 个拷贝/μL 的 SARS-CoV-2 目标基因。这些结果有望最终为开发基于 SERS 的无扩增分子诊断系统奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advancing COVID-19 Diagnosis: Enhancement in SERS-PCR with 30-nm Au Nanoparticle-Internalized Nanodimpled Substrates (Small 46/2024)

Molecular Diagnostic Systems

Using an Au nanoparticles-Au nanodimples (AuNPs-AuNDPs) substrate, in article number 2403672, Sang-Woo Joo, Sung-Gyu Park, Jaebum Choo, and co-workers developed a highly sensitive surface-enhanced Raman scattering (SERS)-polymerase chain reaction molecular diagnostic assay platform capable of detecting 10⁵ copies/μL of the SARS-CoV-2 target gene with a minimal number of thermocycles. These results are expected to ultimately lay the foundation for developing SERS-based amplification-free molecular diagnostic systems.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.