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引用次数: 0
摘要
多环芳香烃（PAHs）暴露与哮喘有关，但其对儿童的个体和综合影响仍不清楚。利用 2003-2012 年美国国家健康与营养调查（NHANES）的数据，我们通过逻辑回归、加权量子和（WQS）回归、量子 g 计算（qg 计算）和贝叶斯核机器回归（BKMR）研究了多环芳烃与哮喘之间的关系。分组分析表明，多环芳烃对哮喘有显著影响，尤其是对男性。WQS 模型显示，9 种 PAHs 对哮喘的综合影响略微显著（Odds Ratio = 1.37，95% 置信区间：1.06-1.75）。BKMR 也表明多环芳烃综合暴露与哮喘之间存在正相关。2-Hydroxyfluorene 和 1-Hydroxypyrene 被确定为最主要的致病因素。这些研究结果表明，混合 PAH 暴露与儿童哮喘风险有关。
The individual and combined effects of polycyclic aromatic hydrocarbons on asthma among US children: evidence from the NHANES study.
Polycyclic Aromatic Hydrocarbons (PAHs) exposure has been linked to asthma, but their individual and combined effects in children remain unclear. Using data from the 2003-2012 National Health and Nutrition Examination Survey (NHANES), we investigated the associations between PAHs and asthma through logistic regression, Weighted Quantile Sum (WQS) regression, Quantile g Computation (qg computation), and Bayesian Kernel Machine Regression (BKMR). Subgroup analyses revealed a significant impact of PAHs on asthma, particularly in males. The WQS model showed a marginally significant combined effect of 9 PAHs on asthma (Odds Ratio = 1.37, 95% Confidence Interval: 1.06-1.75). BKMR also indicated a positive association between combined PAH exposure and asthma. 2-Hydroxyfluorene and 1-Hydroxypyrene were identified as the most significant contributors. These findings suggest that mixed PAH exposure is associated with asthma risk in children.
期刊介绍：
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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