人类和动物接触未避免的多环芳烃:当前的解毒策略和未来展望。

IF 2.2 4区 医学 Q3 ENVIRONMENTAL SCIENCES International Journal of Environmental Health Research Pub Date : 2024-11-20 DOI:10.1080/09603123.2024.2431240
Liyang Yang, Yali Niu, Jianquan Guo
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引用次数: 0

摘要

多环芳烃(PAHs)是一类无处不在的有机化合物,主要产生于有机物的不完全燃烧或热解过程中。多项研究已确认多环芳烃是人类致癌物质,因此必须将其从人类和动物体内清除。为了减轻多环芳烃对人类和动物的不利影响,人们一直在做出巨大的努力。本研究总结了大量用于多环芳烃解毒的技术,包括草药提取、植物化学物质、商业制剂和微生物,以及一些优化策略,但这些技术也存在局限性。改进植物化学物质的给药系统以提高其缓释性和生物利用率,引入新筛选的微生物通过生物降解来解毒多环芳烃,以及利用工程微生物生产植物化学物质和降解酶,是未来需要深入考虑的三个方面。
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Un-avoided polycyclic aromatic hydrocarbons exposure on human and animals: current detoxication strategies and future prospects.

Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous organic compounds mainly produced during the incomplete combustion or pyrolysis of organic materials. Multiple studies have acknowledged PAHs as human carcinogen, which necessitates its detoxication from human and animals. Great and continuous efforts have been made to alleviate the adverse effects of PAHs to human and animals. This study summarizes plenty of techniques, including herbal extraction, phytochemicals, commercial agent and microbes, coupled with some optimized strategies, have utilized for the detoxication of PAHs, which also have limitations. Augmenting the delivery systems of phytochemicals for the improvement of sustained release property and enhancement of the bioavailability, introducing newly screened microbes for PAHs detoxication via biodegrading, as well as engineering microbes for the production of phytochemicals and degradation enzymes are the three future aspects needed to be considered in-depth.

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来源期刊
International Journal of Environmental Health Research
International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.70
自引率
3.10%
发文量
134
审稿时长
>12 weeks
期刊介绍: International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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