Robert M Hazen, Peter C Burns, H James Cleaves Ii, Robert T Downs, Sergey V Krivovichev, Michael L Wong
{"title":"对 \"确定生命阈值需要对装配指数进行实验测量 \"的答复","authors":"Robert M Hazen, Peter C Burns, H James Cleaves Ii, Robert T Downs, Sergey V Krivovichev, Michael L Wong","doi":"10.1098/rsif.2024.0622","DOIUrl":null,"url":null,"abstract":"<p><p>We clarify misunderstandings of Walker et al. (Walker <i>et al.</i> 2024 <i>J. R. Soc. Interface</i> 21, 20240367 (doi:10.1098/rsif.2024.0367)) related to studies of the assembly pathways of molecular subunits in minerals. The finding that these subunits have calculated assembly pathways less than approximately 25 informs a central premise of Assembly Theory-that only life can produce numerous copies of molecules with assembly indices above a threshold value. What that threshold value might be, and whether the same value applies to chemical systems as different as organic and inorganic molecules, are questions deserving of additional study.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240622"},"PeriodicalIF":3.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576840/pdf/","citationCount":"0","resultStr":"{\"title\":\"Reply to 'Experimental measurement of assembly indices are required to determine the threshold for life'.\",\"authors\":\"Robert M Hazen, Peter C Burns, H James Cleaves Ii, Robert T Downs, Sergey V Krivovichev, Michael L Wong\",\"doi\":\"10.1098/rsif.2024.0622\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We clarify misunderstandings of Walker et al. (Walker <i>et al.</i> 2024 <i>J. R. Soc. Interface</i> 21, 20240367 (doi:10.1098/rsif.2024.0367)) related to studies of the assembly pathways of molecular subunits in minerals. The finding that these subunits have calculated assembly pathways less than approximately 25 informs a central premise of Assembly Theory-that only life can produce numerous copies of molecules with assembly indices above a threshold value. What that threshold value might be, and whether the same value applies to chemical systems as different as organic and inorganic molecules, are questions deserving of additional study.</p>\",\"PeriodicalId\":17488,\"journal\":{\"name\":\"Journal of The Royal Society Interface\",\"volume\":\"21 220\",\"pages\":\"20240622\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576840/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Royal Society Interface\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1098/rsif.2024.0622\",\"RegionNum\":2,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Royal Society Interface","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1098/rsif.2024.0622","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
我们澄清了沃克等人（Walker et al. 2024 J. R. Soc. Interface 21, 20240367 (doi:10.1098/rsif.2024.0367)）对矿物中分子亚基组装途径研究的误解。这些亚基的组装路径计算结果小于约 25，这一发现为组装理论提供了一个核心前提--只有生命才能产生大量组装指数超过阈值的分子拷贝。至于这个临界值是多少，以及这个临界值是否适用于有机分子和无机分子这样不同的化学系统，这些问题都值得进一步研究。
Reply to 'Experimental measurement of assembly indices are required to determine the threshold for life'.
We clarify misunderstandings of Walker et al. (Walker et al. 2024 J. R. Soc. Interface 21, 20240367 (doi:10.1098/rsif.2024.0367)) related to studies of the assembly pathways of molecular subunits in minerals. The finding that these subunits have calculated assembly pathways less than approximately 25 informs a central premise of Assembly Theory-that only life can produce numerous copies of molecules with assembly indices above a threshold value. What that threshold value might be, and whether the same value applies to chemical systems as different as organic and inorganic molecules, are questions deserving of additional study.
期刊介绍：
J. R. Soc. Interface welcomes articles of high quality research at the interface of the physical and life sciences. It provides a high-quality forum to publish rapidly and interact across this boundary in two main ways: J. R. Soc. Interface publishes research applying chemistry, engineering, materials science, mathematics and physics to the biological and medical sciences; it also highlights discoveries in the life sciences of relevance to the physical sciences. Both sides of the interface are considered equally and it is one of the only journals to cover this exciting new territory. J. R. Soc. Interface welcomes contributions on a diverse range of topics, including but not limited to; biocomplexity, bioengineering, bioinformatics, biomaterials, biomechanics, bionanoscience, biophysics, chemical biology, computer science (as applied to the life sciences), medical physics, synthetic biology, systems biology, theoretical biology and tissue engineering.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
