Daniel Gussakovsky, Nicole A Black, Evan P Booy, Sean A McKenna
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引用次数: 0
摘要
SRP9/SRP14是一种蛋白质异源二聚体，通过与支架信号识别颗粒RNA（7SL）相互作用，在信号识别颗粒中发挥着关键作用。SRP9/SRP14 与 7SL 的结合是通过与灵长类特异性 Alu RNA 共享的保守结构基序介导的。Alu RNA是Alu元件的转录产物，Alu元件是一种逆转录元件，约占人类基因组的10%。Alu RNA 参与了无数的生物过程，并在多种人类疾病中出现失调。本综述重点探讨 SRP9/SRP14 在调节 Alu RNA 多样化、成熟和功能方面的作用。SRP9/SRP14调控Alu RNA的机制多种多样，体现了蛋白质介导的非编码RNA调控的广泛性。
SRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL). SRP9/SRP14 binding to 7SL is mediated through a conserved structural motif that is shared with the primate-specific Alu RNA. Alu RNA are transcription products of Alu elements, a retroelement that comprises ~10% of the human genome. Alu RNA are involved in myriad biological processes and are dysregulated in several human disease states. This review focuses on the roles SRP9/SRP14 has in regulating Alu RNA diversification, maturation, and function. The diverse mechanisms through which SRP9/SRP14 regulates Alu RNA exemplify the breadth of protein-mediated regulation of non-coding RNA.
期刊介绍：
RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research.
RNA Biology brings together a multidisciplinary community of scientists working in the areas of:
Transcription and splicing
Post-transcriptional regulation of gene expression
Non-coding RNAs
RNA localization
Translation and catalysis by RNA
Structural biology
Bioinformatics
RNA in disease and therapy
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