三维平均疾病缓解率（3D-MDA）：测量睡眠呼吸暂停治疗效果的下一步。

IF 3.8 2区医学 Q1 CLINICAL NEUROLOGY Sleep medicine Pub Date : 2024-11-16 DOI:10.1016/j.sleep.2024.11.027

Thomas M Kaffenberger, Ryan J Soose, Patrick J Strollo, Olivier M Vanderveken

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引用次数: 0

摘要

平均疾病缓解率衡量阻塞性睡眠呼吸暂停（OSA）的治疗效果。它将患者的治疗依从性与他们的总睡眠时间和根据呼吸暂停-低通气指数的变化确定的治疗效果相结合。这一指标未能反映患者与 OSA 相关的症状，而这些症状是决定治疗反应的关键因素，在某些情况下甚至是主要因素。我们提出了一种名为三维平均疾病缓解率（3D-MDA）的增强型指标，它结合了症状反应，能更好地反映真实的治疗效果。结果：所提出的三维平均疾病缓解度量标准旨在通过整合主观影响、治疗依从性和客观疗效，对 OSA 治疗效果进行更全面的评估。此外，随着这些类别的最佳衡量标准不断发展，3D-MDA 也可随时间推移而调整。

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Three-dimensional mean disease alleviation (3D-MDA): The next step in measuring sleep apnea treatment effectiveness.

Mean disease alleviation measures the effectiveness of Obstructive Sleep Apnea (OSA) treatments. It combines a patient's adherence to treatment normalized to their total sleep time and the treatment's efficacy as determined by the change in the apnea-hypopnea index. This metric fails to capture the patient's OSA-related symptoms, which are a key component and, in some cases, the primary component, of determining response to treatment. We propose an enhanced metric called three-dimensional mean disease alleviation (3D-MDA), which incorporates the symptom response to better reflect the true treatment impact. RESULTS: The proposed 3D-MDA metric aims to provide a more comprehensive assessment of OSA treatment effectiveness by integrating the subjective impact, therapy adherence, and objective efficacy. Further, 3D-MDA is adaptable over time as the optimal metrics for these categories continue to evolve.

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来源期刊

Sleep medicine 医学-临床神经学

CiteScore

8.40

自引率

6.20%

发文量

1060

审稿时长

49 days

期刊介绍： Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.