从 1929 年至 2004 年间出生的 560 000 对亲属中对儿童身高遗传性进行的元分析》(Meta-Analysis of Heritability of Childhood Height from 560 000 Pairs of Relatives Born between 1929 and 2004)。

IF 1.6 4区 医学 Q1 ANTHROPOLOGY American Journal of Human Biology Pub Date : 2024-11-20 DOI:10.1002/ajhb.24188
Reta Dewau, Aafke Boomsma, Caitlin Doyle, Stephanie Byrne, Elina Hyppönen, Sang Hong Lee, Beben Benyamin
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引用次数: 0

摘要

背景:儿童身高通常用于衡量儿童的健康和营养状况。如果儿童身高比《儿童生长标准》中位数低两个标准差以上,则被视为发育迟缓。研究表明,遗传和环境因素对儿童身高有影响,因此了解这些因素对发育迟缓研究非常重要。本系统综述和荟萃分析研究了这些因素在不同研究设计和不同血统中的作用:系统性检索发现了 28 项双胞胎研究和 26 项家族研究,研究时间跨度从出生到 17 岁。我们确定了 1929 年至 2004 年间出生的 162 293 对双胞胎、380 195 对父母-后代和 19 965 对兄弟姐妹。我们采用随机效应模型对这些数据集进行了元分析。综述已在 PROSPERO(ID CRD42023432550)上注册:结果:从双胞胎设计得出的身高估计遗传率(h2)从出生到 17 岁不断上升。对于 5 岁以下儿童,欧洲血统的估计遗传率为 0.57(95%CI,0.52-0.61),亚洲血统为 0.48(0.39-0.57),多血统为 0.46(0.40-0.51)。根据亲代-子代设计估计,出生时的遗传率为 0.46(95%CI,0.28-0.62),17 岁时为 0.76(95%CI,0.70-0.80)。同时,兄弟姐妹设计的遗传率估计值在各年龄段保持不变,为 0.70 (95%CI, 0.52-0.83):结论:欧洲血统的儿童身高遗传率估计值略高,但总体而言,不同血统群体的遗传率估计值差异不大。虽然共同环境对身高的影响在儿童早期达到顶峰,但估计的遗传率在青少年晚期有所增加。独特的环境因素在整个儿童期的作用虽小,但却很重要。
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Meta-Analysis of the Heritability of Childhood Height From 560 000 Pairs of Relatives Born Between 1929 and 2004.

Background: Childhood height is commonly used to measure children's health and nutritional status. It is used to define stunting, where a child is considered stunted if their height is shorter than two standard deviations below the Child Growth Standards median. Studies have shown that genetic and environmental factors contribute to childhood height, so understanding these contributions is important for stunting research. This systematic review and meta-analysis examined the contribution of these factors across study designs and ancestries.

Methods: A systematic search found 28 twin and 26 family studies spanning from birth to 17 years. We identified 162 293 twin, 380 195 parent-offspring, and 19 965 sibling pairs born between 1929 and 2004. These datasets were meta-analyzed using a random effects model. The review is registered in PROSPERO (ID CRD42023432550).

Results: The estimated heritability (h2) of height from twin design increased from birth to 17 years. For children under 5 years, the estimated heritability was 0.57 (95%CI, 0.52-0.61) for European, 0.48 (0.39-0.57) for Asian, and 0.46 (0.40-0.51) for multi ancestries. Heritability estimated from parent-offspring design was 0.46 (95%CI, 0.28-0.62) at birth and 0.76 (95%CI, 0.70-0.80) at 17 years. Meanwhile, the estimated heritability from sibling design remained constant across ages at 0.70 (95%CI, 0.52-0.83).

Conclusions: The heritability estimates of childhood height were slightly higher in European ancestries, but in general, they did not significantly differ across ancestry groups. While the shared environmental effects on height peak in early childhood, the estimated heritability increase in late teens. Unique environmental factors play a small, but significant role throughout childhood.

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来源期刊
CiteScore
4.80
自引率
13.80%
发文量
124
审稿时长
4-8 weeks
期刊介绍: The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.
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