Ziyang Liu, Ali Ajam, Jun Huang, Yu-Sheng Yeh, Babak Razani
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Glutamine–glutamate imbalance in the pathogenesis of cardiovascular disease
Glutaminase-2 (GLS2) is crucial for glutamine metabolism and its deficiency causes increased plasma glutamine levels, disrupted extracellular matrix remodeling and accelerated plaque progression. Findings reveal a metabolic link between hepatic glutamine homeostasis and the vasculature and potential therapeutic strategies for cardiovascular disease.
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