Xiangli Li , Wen-Jing Tang , Wei Wang , Shuzhen Yue , Huiqin Yao , Jun-Jie Zhu
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引用次数: 0
摘要
本文开发了一种酸响应脂质体纳米药物，用于光声（PA）成像引导的氧气（O2）依赖性声动力疗法（SDT）。这种脂质体纳米药物具有以下几个优点：(i) 在超声波照射下，它能促进不依赖于氧气的烷基自由基的生成；(ii) 它具有酸响应电荷还原性，能增强肿瘤穿透力；(iii) 它能进行活化 PA 成像以获得治疗反馈。
Acid-responsive liposomal nanodrug with promoted tumor penetration for photoacoustic imaging-guided sonodynamic therapy†
Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O2)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O2-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.
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