{"title":"促进肿瘤穿透的酸响应脂质体纳米药物用于光声成像引导的声动力疗法","authors":"Xiangli Li, Wen-Jing Tang, Wei Wang, Shuzhen Yue, Huiqin Yao, Jun-Jie Zhu","doi":"10.1039/d4cc05043f","DOIUrl":null,"url":null,"abstract":"Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O<small><sub>2</sub></small>)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O<small><sub>2</sub></small>-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acid-Responsive Liposomal Nanodrug with promoted Tumor Penetration for Photoacoustic Imaging-Guided Sonodynamic Therapy\",\"authors\":\"Xiangli Li, Wen-Jing Tang, Wei Wang, Shuzhen Yue, Huiqin Yao, Jun-Jie Zhu\",\"doi\":\"10.1039/d4cc05043f\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O<small><sub>2</sub></small>)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O<small><sub>2</sub></small>-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"60 1\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d4cc05043f\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc05043f","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
本文开发了一种酸响应脂质体纳米药物，用于光声（PA）成像引导的氧气（O2）依赖性声动力疗法（SDT）。这种脂质体纳米药物具有以下几个优点：(i) 在超声波照射下，它能促进不依赖于氧气的烷基自由基的生成；(ii) 它具有酸响应电荷还原性，能增强肿瘤穿透力；(iii) 它能进行活化 PA 成像以获得治疗反馈。
Acid-Responsive Liposomal Nanodrug with promoted Tumor Penetration for Photoacoustic Imaging-Guided Sonodynamic Therapy
Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O2)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O2-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.
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