{"title":"闪耀的光芒打破平面性","authors":"Ricardo J. Fernández-Terán","doi":"10.1038/s41929-024-01254-w","DOIUrl":null,"url":null,"abstract":"The synthesis of rigid C(sp3)-rich isosteric mimics of heteroaromatic rings has proved a significant challenge, but is of importance in drug discovery. Now, two studies report the synthesis of densely functionalized azetidines and bicycloalkanes, using a similar concept of breaking planarity.","PeriodicalId":18845,"journal":{"name":"Nature Catalysis","volume":"7 11","pages":"1151-1153"},"PeriodicalIF":42.8000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Shining light to break planarity\",\"authors\":\"Ricardo J. Fernández-Terán\",\"doi\":\"10.1038/s41929-024-01254-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The synthesis of rigid C(sp3)-rich isosteric mimics of heteroaromatic rings has proved a significant challenge, but is of importance in drug discovery. Now, two studies report the synthesis of densely functionalized azetidines and bicycloalkanes, using a similar concept of breaking planarity.\",\"PeriodicalId\":18845,\"journal\":{\"name\":\"Nature Catalysis\",\"volume\":\"7 11\",\"pages\":\"1151-1153\"},\"PeriodicalIF\":42.8000,\"publicationDate\":\"2024-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Catalysis\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.nature.com/articles/s41929-024-01254-w\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Catalysis","FirstCategoryId":"92","ListUrlMain":"https://www.nature.com/articles/s41929-024-01254-w","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
The synthesis of rigid C(sp3)-rich isosteric mimics of heteroaromatic rings has proved a significant challenge, but is of importance in drug discovery. Now, two studies report the synthesis of densely functionalized azetidines and bicycloalkanes, using a similar concept of breaking planarity.
期刊介绍：
Nature Catalysis serves as a platform for researchers across chemistry and related fields, focusing on homogeneous catalysis, heterogeneous catalysis, and biocatalysts, encompassing both fundamental and applied studies. With a particular emphasis on advancing sustainable industries and processes, the journal provides comprehensive coverage of catalysis research, appealing to scientists, engineers, and researchers in academia and industry.
Maintaining the high standards of the Nature brand, Nature Catalysis boasts a dedicated team of professional editors, rigorous peer-review processes, and swift publication times, ensuring editorial independence and quality. The journal publishes work spanning heterogeneous catalysis, homogeneous catalysis, and biocatalysis, covering areas such as catalytic synthesis, mechanisms, characterization, computational studies, nanoparticle catalysis, electrocatalysis, photocatalysis, environmental catalysis, asymmetric catalysis, and various forms of organocatalysis.
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