高海拔环境中的认知损伤机制:蛋白质组和代谢组的启示。

IF 3.8 2区 生物学 Q1 BIOCHEMICAL RESEARCH METHODS Journal of Proteome Research Pub Date : 2024-12-06 Epub Date: 2024-11-20 DOI:10.1021/acs.jproteome.4c00841
Qin Zhao, Jinli Meng, Li Feng, Suyuan Wang, Kejin Xiang, Yonghong Huang, Hengyan Li, Xiaomei Li, Xin Hu, Lu Che, Yongxing Fu, Liming Zhao, Yunhong Wu, Wanlin He
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引用次数: 0

摘要

高海拔暴露会对神经认知功能产生不利影响;然而,其背后的机制仍然难以捉摸。高海拔暴露为何以及如何损害神经认知功能,尤其是睡眠?本研究旨在确定相关的分子标记和机制,从而制定预防和缓解高原反应的策略。我们利用血清蛋白质组学和代谢组学,分析了 23 名汉族平原居民在西藏高海拔地区工作 6 个月前后的血液样本。相关分析揭示了与认知改变相关的生物标志物。六个月的高海拔暴露严重损害了认知功能,尤其是睡眠质量。与之相关的关键生物标志物包括 SEPTIN5、PCBP1、STIM1、UBE2L3/I/N、氨基酸(l/d-天冬氨酸和 l-谷氨酸)、花生四烯酸和 S1P。免疫和神经信号传导受到抑制,并观察到性别差异。这项研究创新性地将 GABA、花生四烯酸、l-谷氨酸、2-丙烯酰甘油和 d-天冬氨酸确定为生物标志物,并阐明了导致高海拔诱导的神经认知功能下降的潜在机制,其中特别关注睡眠干扰。这些发现为制定预防措施和加强适应策略铺平了道路。这项研究强调了高海拔适应的生理意义,提出了有关性别特异性反应和长期后果的新问题。它为今后探索个体差异和干预效果的研究奠定了基础。
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Cognitive Impairment Mechanisms in High-Altitude Exposure: Proteomic and Metabolomic Insights.

High-altitude exposure can adversely affect neurocognitive functions; however, the underlying mechanisms remain elusive. Why and how does high-altitude exposure impair neurocognitive functions, particularly sleep? This study seeks to identify the molecular markers and mechanisms involved, with the goal of forming prevention and mitigation strategies for altitude sickness. Using serum proteomics and metabolomics, we analyzed blood samples from 23 Han Chinese plain dwellers before and after six months of high-altitude work in Tibet. The correlation analysis revealed biomarkers associated with cognitive alterations. Six months of high-altitude exposure significantly compromised cognitive function, notably, sleep quality. The key biomarkers implicated include SEPTIN5, PCBP1, STIM1, UBE2L3/I/N, amino acids (l/d-aspartic acid and l-glutamic acid), arachidonic acid, and S1P. Immune and neural signaling were suppressed, with sex-specific differences observed. This study innovatively identified GABA, arachidonic acid, l-glutamic acid, 2-arachidonoyl glycerol, and d-aspartic acid as biomarkers and elucidated the underlying mechanisms contributing to high-altitude-induced neurocognitive decline with a particular focus on sleep disruption. These findings pave the way for developing preventive measures and enhancing adaptation strategies. This study underscores the physiological significance of high-altitude adaptation, raising new questions about sex-specific responses and long-term consequences. It sets the stage for future research exploring individual variability and intervention efficacy.

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来源期刊
Journal of Proteome Research
Journal of Proteome Research 生物-生化研究方法
CiteScore
9.00
自引率
4.50%
发文量
251
审稿时长
3 months
期刊介绍: Journal of Proteome Research publishes content encompassing all aspects of global protein analysis and function, including the dynamic aspects of genomics, spatio-temporal proteomics, metabonomics and metabolomics, clinical and agricultural proteomics, as well as advances in methodology including bioinformatics. The theme and emphasis is on a multidisciplinary approach to the life sciences through the synergy between the different types of "omics".
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