端粒：连接植物和哺乳动物的一根有组织的线。

IF 5.7 2区生物学 Q1 BIOLOGY Biology Direct Pub Date : 2024-11-20 DOI:10.1186/s13062-024-00558-y

Edison Di Pietro, Romina Burla, Mattia La Torre, Mary-Paz González-García, Raffaele Dello Ioio, Isabella Saggio

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引用次数: 0

摘要

端粒是决定细胞干性、生物衰老和寿命的关键因素。在这里，我们研究了拟南芥、小鼠和人类端粒的相似性。我们报告了它们的共同特征，包括由 TTAGGG 序列组成的多聚体以及由专门蛋白质保护的端粒。此外，鉴于端粒与细胞增殖和干性之间的联系，我们讨论了植物和哺乳动物在这方面的反直觉趋同性，重点是龛位对细胞干性的影响。最后，我们认为，通过同时考虑植物和哺乳动物来研究端粒功能和细胞干性，有助于理解两者之间的相互联系，并有助于以衰老和生物体寿命决定因素为重点的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Telomeres: an organized string linking plants and mammals.

Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which include their composition in multimers of TTAGGG sequences and their protection by specialized proteins. Moreover, given the link between telomeres, on the one hand, and cell proliferation and stemness on the other, we discuss the counterintuitive convergence between plants and mammals in this regard, focusing on the impact of niches on cell stemness. Finally, we suggest that tackling the study of telomere function and cell stemness by taking into consideration both plants and mammals can aid in the understanding of interconnections and contribute to research focusing on aging and organismal lifespan determinants.

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来源期刊

Biology Direct 生物-生物学

CiteScore

6.40

自引率

10.90%

发文量

审稿时长

7 months

期刊介绍： Biology Direct serves the life science research community as an open access, peer-reviewed online journal, providing authors and readers with an alternative to the traditional model of peer review. Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in subject areas currently identified as those most conducive to the open review approach, primarily those with a significant non-experimental component.