Zhijun Chen, Guotao Yang, Weiping Su, Shuangjun He, Yaowei Wang
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The diagnostic value of serum IL-6 and TGF-β1 was assessed with ROC curves and MedCalc software.</p><p><strong>Results: </strong>Smoking history, drinking history, lumbar spine BMD, femoral neck BMD, PINP, and β-CTX markedly differed among the normal bone mass, osteopenia, and OP groups. Elevated IL-6 and reduced TGF-β1 concentrations were observed in serum samples of OP. Serum IL-6 concentrations was inversely associated with bone density markers but positively lined to bone turnover markers. Conversely, serum TGF-β1 was positively related to bone density markers but negatively associated with bone turnover markers. Smoking history, PINP, and IL-6, were identified as independent risk factors while lumbar spine BMD, femoral neck BMD, and TGF-β1 were independent protective markers for OP. The combined assessment of serum IL-6 and TGF-β1 showed superior diagnostic performance for OP.</p><p><strong>Conclusion: </strong>Serum IL-6 in combination with TGF-β1 exhibits good diagnostic performance for OP.</p><p><strong>Level of evidence: </strong>Diagnostic: individual cross-sectional studies with consistently applied reference standard and blinding.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum IL-6 and TGF-β1 concentrations as diagnostic biomarkers in elderly male patients with osteoporosis.\",\"authors\":\"Zhijun Chen, Guotao Yang, Weiping Su, Shuangjun He, Yaowei Wang\",\"doi\":\"10.1007/s00586-024-08553-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This research is intended to evaluate the correlations of serum IL-6 and TGF-β1 concentrations with bone density and turnover markers as well as their diagnostic value in elderly male patients with osteoporosis (OP).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 335 elderly men (≥ 60 years; 90 with normal bone mass, 120 osteopenia cases, and 125 OP cases). 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引用次数: 0
摘要
目的：本研究旨在评估老年男性骨质疏松症（OP）患者血清中 IL-6 和 TGF-β1 浓度与骨密度和骨转换指标的相关性及其诊断价值：对 335 名老年男性（≥ 60 岁；90 例骨质正常，120 例骨质疏松症，125 例 OP）进行了回顾性分析。腰椎/股骨颈 BMD 值是通过双能 X 射线吸收测定法测量的。利用皮尔逊或斯皮尔曼相关系数分析了 OP 患者血清 IL-6 和 TGF-β1 浓度与骨密度和骨转换指标的相关性。通过逻辑多元回归分析确定了 OP 的独立影响因素。利用 ROC 曲线和 MedCalc 软件评估了血清 IL-6 和 TGF-β1 的诊断价值：吸烟史、饮酒史、腰椎 BMD、股骨颈 BMD、PINP 和 β-CTX 在正常骨量组、骨质疏松组和 OP 组之间存在明显差异。在 OP 组血清样本中观察到 IL-6 浓度升高，TGF-β1 浓度降低。血清 IL-6 浓度与骨密度指标成反比，但与骨转换指标成正比。相反，血清 TGF-β1 与骨密度指标呈正相关，但与骨转换指标呈负相关。吸烟史、PINP 和 IL-6 被确定为 OP 的独立风险因素，而腰椎 BMD、股骨颈 BMD 和 TGF-β1 则是 OP 的独立保护标志物。综合评估血清IL-6和TGF-β1对OP的诊断效果更佳：结论：血清IL-6和TGF-β1联合检测对OP具有良好的诊断效果：诊断：具有一致参考标准和盲法的个体横断面研究。
Serum IL-6 and TGF-β1 concentrations as diagnostic biomarkers in elderly male patients with osteoporosis.
Purpose: This research is intended to evaluate the correlations of serum IL-6 and TGF-β1 concentrations with bone density and turnover markers as well as their diagnostic value in elderly male patients with osteoporosis (OP).
Methods: A retrospective analysis was conducted on 335 elderly men (≥ 60 years; 90 with normal bone mass, 120 osteopenia cases, and 125 OP cases). Lumbar spine/femoral neck BMD values were measured using dual-energy X-ray absorptiometry. Correlations of serum IL-6 and TGF-β1 concentrations with bone density and bone turnover markers in OP patients were analyzed utilizing Pearson or Spearman correlation coefficients. Independent influencing factors for OP were identified by logistic multivariate regression analysis. The diagnostic value of serum IL-6 and TGF-β1 was assessed with ROC curves and MedCalc software.
Results: Smoking history, drinking history, lumbar spine BMD, femoral neck BMD, PINP, and β-CTX markedly differed among the normal bone mass, osteopenia, and OP groups. Elevated IL-6 and reduced TGF-β1 concentrations were observed in serum samples of OP. Serum IL-6 concentrations was inversely associated with bone density markers but positively lined to bone turnover markers. Conversely, serum TGF-β1 was positively related to bone density markers but negatively associated with bone turnover markers. Smoking history, PINP, and IL-6, were identified as independent risk factors while lumbar spine BMD, femoral neck BMD, and TGF-β1 were independent protective markers for OP. The combined assessment of serum IL-6 and TGF-β1 showed superior diagnostic performance for OP.
Conclusion: Serum IL-6 in combination with TGF-β1 exhibits good diagnostic performance for OP.
Level of evidence: Diagnostic: individual cross-sectional studies with consistently applied reference standard and blinding.
期刊介绍：
"European Spine Journal" is a publication founded in response to the increasing trend toward specialization in spinal surgery and spinal pathology in general. The Journal is devoted to all spine related disciplines, including functional and surgical anatomy of the spine, biomechanics and pathophysiology, diagnostic procedures, and neurology, surgery and outcomes. The aim of "European Spine Journal" is to support the further development of highly innovative spine treatments including but not restricted to surgery and to provide an integrated and balanced view of diagnostic, research and treatment procedures as well as outcomes that will enhance effective collaboration among specialists worldwide. The “European Spine Journal” also participates in education by means of videos, interactive meetings and the endorsement of educative efforts.
Official publication of EUROSPINE, The Spine Society of Europe
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