Pub Date : 2025-12-19DOI: 10.1007/s00586-025-09634-x
Marta Rodrigues Carvalho, Vitor Caldas Marques, Baldomero Pinto Soares, Gabriel Pokorny, Thiego Pedro, Mario Bringel, Rodrigo Grion
Background: The Hoffmann (H-) reflex is a monosynaptic electrophysiological response that reflects S1-root integrity. Although widely used in experimental and in clinical outpatient neurophysiological testing, its intra-operative application during endoscopic lumbar surgery is rarely reported. We present the first real-time documentation of H-reflex normalization immediately after endoscopic decompression of an acute L5-S1 disc herniation.
Case description: A 49-year-old woman presented with acute right-sided S1 radiculopathy (ankle dorsiflexion/plantar-flexion MRC grade III; hallux extension grade I). MRI showed a large, right sub-articular L5-S1 disc extrusion compressing the S1 nerve root. Unilateral biportal endoscopic discectomy was performed under general anesthesia with multimodal intra-operative neuromonitoring (MEPs, free-run EMG, and continuous tibial-nerve H-reflex). Baseline recordings revealed marked side-to-side asymmetry: right-leg MEP amplitudes were depressed, and the right H-reflex was low and unstable. During foraminoplasty and fragment removal, a sudden, sustained 100% surge in right H-reflex amplitude occurred, coincidence with root decompression, while MEPs remained unchanged. Free-run EMG discharges abated after the H-reflex improved. Post-operative recovery was uneventful. At 2 months the patient demonstrated near-complete motor recovery (MRC IV-V) and full pain relief.
Conclusion: Continuous H-reflex monitoring provided an immediate, sensitive marker of S1-root decompression when conventional MEPs failed to reflect functional recovery. This single-case experience supports the feasibility and potential prognostic value of adding H-reflex surveillance to the neuromonitoring toolkit for endoscopic lumbar surgery. Prospective studies in larger cohorts are warranted to validate threshold criteria, refine stimulation parameters, and determine cost-effectiveness.
{"title":"Old technique, new applications: can the H-reflex be a possible real-time indicator in endoscopic surgery for decompression of acute disc herniation at the S1 root?","authors":"Marta Rodrigues Carvalho, Vitor Caldas Marques, Baldomero Pinto Soares, Gabriel Pokorny, Thiego Pedro, Mario Bringel, Rodrigo Grion","doi":"10.1007/s00586-025-09634-x","DOIUrl":"https://doi.org/10.1007/s00586-025-09634-x","url":null,"abstract":"<p><strong>Background: </strong>The Hoffmann (H-) reflex is a monosynaptic electrophysiological response that reflects S1-root integrity. Although widely used in experimental and in clinical outpatient neurophysiological testing, its intra-operative application during endoscopic lumbar surgery is rarely reported. We present the first real-time documentation of H-reflex normalization immediately after endoscopic decompression of an acute L5-S1 disc herniation.</p><p><strong>Case description: </strong>A 49-year-old woman presented with acute right-sided S1 radiculopathy (ankle dorsiflexion/plantar-flexion MRC grade III; hallux extension grade I). MRI showed a large, right sub-articular L5-S1 disc extrusion compressing the S1 nerve root. Unilateral biportal endoscopic discectomy was performed under general anesthesia with multimodal intra-operative neuromonitoring (MEPs, free-run EMG, and continuous tibial-nerve H-reflex). Baseline recordings revealed marked side-to-side asymmetry: right-leg MEP amplitudes were depressed, and the right H-reflex was low and unstable. During foraminoplasty and fragment removal, a sudden, sustained 100% surge in right H-reflex amplitude occurred, coincidence with root decompression, while MEPs remained unchanged. Free-run EMG discharges abated after the H-reflex improved. Post-operative recovery was uneventful. At 2 months the patient demonstrated near-complete motor recovery (MRC IV-V) and full pain relief.</p><p><strong>Conclusion: </strong>Continuous H-reflex monitoring provided an immediate, sensitive marker of S1-root decompression when conventional MEPs failed to reflect functional recovery. This single-case experience supports the feasibility and potential prognostic value of adding H-reflex surveillance to the neuromonitoring toolkit for endoscopic lumbar surgery. Prospective studies in larger cohorts are warranted to validate threshold criteria, refine stimulation parameters, and determine cost-effectiveness.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1007/s00586-025-09686-z
Zhuoyue Li, Shangjie Yang, Chaoran Li, Lin Zhang, Na Xi, Dawei Li, Litao Li
{"title":"Metagenomic next-generation sequencing for the diagnosis of suspected spinal infections from biopsy samples: a novel biopsy toolkit design and real-life diagnostic value.","authors":"Zhuoyue Li, Shangjie Yang, Chaoran Li, Lin Zhang, Na Xi, Dawei Li, Litao Li","doi":"10.1007/s00586-025-09686-z","DOIUrl":"https://doi.org/10.1007/s00586-025-09686-z","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1007/s00586-025-09694-z
Changzhu Lu, Long Zheng
{"title":"Letter to the Editor concerning \"Mortality for pneumonia and risk of pneumonia in children with cerebral palsy treated with and without surgery\" by Ahonen, et al. (Eur Spine J [2025]; doi: 10.1007/s00586-025-09625-y).","authors":"Changzhu Lu, Long Zheng","doi":"10.1007/s00586-025-09694-z","DOIUrl":"https://doi.org/10.1007/s00586-025-09694-z","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1007/s00586-025-09682-3
Joshua G Sanchez, Julian Smith-Voudouris, Katie M Zehner, Scott J Halperin, Sahir S Jabbouri, Anthony E Seddio, Daniel R Rubio, Jonathan N Grauer
Purpose: Endoscopic spine surgery (ESS) may reduce perioperative risks traditionally associated with obesity in open lumbar procedures. This study evaluated 90-day complications, healthcare utilization, and insurer-payments in obese versus non-obese patients undergoing endoscopic lumbar decompression.
Methods: A national administrative database was queried for adults undergoing endoscopic lumbar decompression from January 2017 to April 2023. Patients with trauma, neoplasm, or infection within 90-days preoperatively or < 90-day follow-up postoperatively were excluded. Cohorts were stratified by obesity (body mass index > 30 kg/m²). Demographics, 90-day complications (any, severe, minor), and healthcare utilization (emergency department visits, readmissions, physical therapy) were compared using univariable tests and multivariable logistic regression adjusting for age, sex, Elixhauser Comorbidity Index, smoking, type 2 diabetes, hypertension, obstructive sleep apnea, and surgical indication (stenosis vs. disc herniation). Ninety-day insurer payments were compared using a Wilcoxon rank-sum test.
Results: A total of 1,989 patients met criteria (1618 non-obese; 371 obese). On univariable and multivariable analysis, obesity was not associated with increased odds of any 90-day complication or healthcare-utilization outcome. Median (25th quartile, 75th quartile) 90-day insurer-payments were $2563 ($1074, 5124) for non-obese patients and $3310 ($1572, 5784) for obese patients (p = 0.0003).
Conclusion: This study demonstrated obesity was not associated with increased odds of 90-day complications or healthcare utilization in the adjusted models. However, obese patients incurred higher insurer-paid costs, underscoring important clinical and policy considerations. As ESS becomes increasingly utilized, future work should examine patient-reported outcomes, longer-term complications, and reoperation-free survival in obese patients as well as in populations with other comorbidities.
{"title":"Endoscopic lumbar decompression in patients with obesity does not correlate with inferior outcomes.","authors":"Joshua G Sanchez, Julian Smith-Voudouris, Katie M Zehner, Scott J Halperin, Sahir S Jabbouri, Anthony E Seddio, Daniel R Rubio, Jonathan N Grauer","doi":"10.1007/s00586-025-09682-3","DOIUrl":"https://doi.org/10.1007/s00586-025-09682-3","url":null,"abstract":"<p><strong>Purpose: </strong>Endoscopic spine surgery (ESS) may reduce perioperative risks traditionally associated with obesity in open lumbar procedures. This study evaluated 90-day complications, healthcare utilization, and insurer-payments in obese versus non-obese patients undergoing endoscopic lumbar decompression.</p><p><strong>Methods: </strong>A national administrative database was queried for adults undergoing endoscopic lumbar decompression from January 2017 to April 2023. Patients with trauma, neoplasm, or infection within 90-days preoperatively or < 90-day follow-up postoperatively were excluded. Cohorts were stratified by obesity (body mass index > 30 kg/m²). Demographics, 90-day complications (any, severe, minor), and healthcare utilization (emergency department visits, readmissions, physical therapy) were compared using univariable tests and multivariable logistic regression adjusting for age, sex, Elixhauser Comorbidity Index, smoking, type 2 diabetes, hypertension, obstructive sleep apnea, and surgical indication (stenosis vs. disc herniation). Ninety-day insurer payments were compared using a Wilcoxon rank-sum test.</p><p><strong>Results: </strong>A total of 1,989 patients met criteria (1618 non-obese; 371 obese). On univariable and multivariable analysis, obesity was not associated with increased odds of any 90-day complication or healthcare-utilization outcome. Median (25th quartile, 75th quartile) 90-day insurer-payments were $2563 ($1074, 5124) for non-obese patients and $3310 ($1572, 5784) for obese patients (p = 0.0003).</p><p><strong>Conclusion: </strong>This study demonstrated obesity was not associated with increased odds of 90-day complications or healthcare utilization in the adjusted models. However, obese patients incurred higher insurer-paid costs, underscoring important clinical and policy considerations. As ESS becomes increasingly utilized, future work should examine patient-reported outcomes, longer-term complications, and reoperation-free survival in obese patients as well as in populations with other comorbidities.</p>","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Answer to the Letter to the Editor of H. Wang, et al. concerning \"5G-Enabled remote Robotic-Assisted percutaneous pedicle screw fixation in single thoracolumbar fractures: initial clinical feasibility and safety evaluation\" by L. Zhou, et al. (Eur Spine J [2025]: doi: 10.1007/s00586-025-09478-5).","authors":"Lu-Ping Zhou, Xian-Liang Zhang, Hua-Qing Zhang, Yu Chen, Chong-Yu Jia, Peng Ge, Yong Zhang, Ao Liu, Ren-Jie Zhang, Cai-Liang Shen","doi":"10.1007/s00586-025-09557-7","DOIUrl":"https://doi.org/10.1007/s00586-025-09557-7","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1007/s00586-025-09586-2
Baris Kucukyuruk, Huseyin Mert Cerci, Fatma Serra Kalyoncu, Irem Karaboga, Semih Can Cetintas, Osman Aykan Kargin, Bora Korkmazer, Serdar Arslan, Mehmet Murat Hanci
{"title":"Evaluation of spinal canal and neural foramen areas in supine and prone positions in patients with lumbar stenosis.","authors":"Baris Kucukyuruk, Huseyin Mert Cerci, Fatma Serra Kalyoncu, Irem Karaboga, Semih Can Cetintas, Osman Aykan Kargin, Bora Korkmazer, Serdar Arslan, Mehmet Murat Hanci","doi":"10.1007/s00586-025-09586-2","DOIUrl":"https://doi.org/10.1007/s00586-025-09586-2","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1007/s00586-025-09665-4
Shyam Sundar Sah, Abhishek Kumbhalwar
{"title":"Letter to the Editor concerning \"Association between MRI findings and inflammatory symptoms in non-specific chronic low back pain\" by K. Ziegeler, et al. (Eur Spine J [2025]; doi: 10.1007/s00586-025-09492-7).","authors":"Shyam Sundar Sah, Abhishek Kumbhalwar","doi":"10.1007/s00586-025-09665-4","DOIUrl":"https://doi.org/10.1007/s00586-025-09665-4","url":null,"abstract":"","PeriodicalId":12323,"journal":{"name":"European Spine Journal","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}