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引用次数: 0
摘要
雷帕霉素靶蛋白激酶（TOR）是植物生长和发育的关键调控因子，它整合环境和内部信号来调节细胞过程。本综述探讨了 TOR 在染色质调控中新出现的作用，重点是其核活动以及与染色质重塑因子的相互作用。我们强调了 TOR 影响染色质结构和基因表达的机制，包括参与组蛋白修饰和 DNA 甲基化。此外，综述还讨论了 TOR 信号、细胞骨架和核功能之间的相互作用，强调了 TOR 作为细胞骨架动态和染色质调控之间桥梁的潜力。最后，除了 TOR 介导的细胞核穿梭和代谢调控外，我们还讨论了 TOR 对染色质成分的翻译控制，这是影响染色质景观的另一个层面。我们还提出了未来的研究方向，以进一步阐明 TOR 在植物细胞中的复杂调控网络。
TORquing chromatin: the regulatory role of TOR kinase on chromatin function.
The Target of Rapamycin (TOR) kinase is a critical regulator of plant growth and development, integrating environmental and internal signals to modulate cellular processes. This review explores the emerging role of TOR in chromatin regulation, with a focus on its nuclear activities and interactions with chromatin remodeling factors. We highlight the mechanisms by which TOR influences chromatin structure and gene expression, including its involvement in histone modifications and DNA methylation. Additionally, the review discusses the interplay between TOR signaling, the cytoskeleton, and nuclear functions, emphasizing the potential of TOR to act as a bridge between cytoskeletal dynamics and chromatin regulation. Finally, besides TOR-mediated cyto-nuclear shuttling and metabolic regulation, we address the translational control of chromatin components by TOR as additional layers impacting the chromatin landscape. We also propose future research directions to further elucidate the complex regulatory network governed by TOR in plant cells.
期刊介绍：
The Journal of Experimental Botany publishes high-quality primary research and review papers in the plant sciences. These papers cover a range of disciplines from molecular and cellular physiology and biochemistry through whole plant physiology to community physiology.
Full-length primary papers should contribute to our understanding of how plants develop and function, and should provide new insights into biological processes. The journal will not publish purely descriptive papers or papers that report a well-known process in a species in which the process has not been identified previously. Articles should be concise and generally limited to 10 printed pages.
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