{"title":"代谢健康的肥胖与视网膜年龄差距的关系。","authors":"Xiaomin Zeng, Ruiye Chen, Gabriella Bulloch, Qingsheng Peng, Ching-Yu Cheng, Mingguang He, Honghua Yu, Zhuoting Zhu","doi":"10.1167/tvst.13.11.26","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We investigated the association between metabolically healthy obesity (MHO) and retinal age gap and explored potential sex differences in this association.</p><p><strong>Methods: </strong>This study included 30,335 participants from the UK Biobank. Body mass index (BMI) was classified into normal weight, overweight, and obesity. Metabolic health (MH) was defined as meeting the following criteria: systolic blood pressure of <130 mm Hg, no antihypertensive drugs, waist-to-hip ratio of <0.95 for women or 1.03 for men, and the absence of diabetes. Participants were categorized as MH normal weight (MHN), MH overweight (MHOW), MHO, metabolically unhealthy normal weight, metabolically unhealthy (MU) overweight, and MU obesity. Retinal age gap was defined as the difference between retinal age and chronological age. Linear regression models were used to investigate the association of metabolic phenotypes of obesity with retinal age gap.</p><p><strong>Results: </strong>Compared with MHN, individuals with MHOW (β, 0.17; 95% confidence interval [CI], 0.01-0.32; P = 0.039) and MHO (β, 0.23; 95% CI, 0.02-0.44; P = 0.031) were associated with increased retinal age gap. Furthermore, individuals classified as metabolic unhealthy were also associated with higher retinal age gap, irrespective of body mass index categories (β for MU normal weight, 0.23; 95% CI, 0.08-0.38; P = 0.003; β for MU overweight: 0.31; 95% CI, 0.18-0.45; P < 0.001; β for MU obesity, 0.50; 95% CI, 0.36-0.65; P < 0.001). No significant sex difference was observed in the association between metabolic phenotypes of obesity and retinal age gap (all P for interaction > 0.05).</p><p><strong>Conclusions: </strong>MHOW and MHO were associated significantly with an increased retinal age gap compared with MHN individuals. Weight management should be recommended for individuals who are overweight or obese, even in the absence of metabolic unhealth.</p><p><strong>Translational relevance: </strong>Retinal age gap provides a simple tool for identifying early health risks for MHOW and MHO individuals.</p>","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"13 11","pages":"26"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585067/pdf/","citationCount":"0","resultStr":"{\"title\":\"Associations of Metabolically Healthy Obesity and Retinal Age Gap.\",\"authors\":\"Xiaomin Zeng, Ruiye Chen, Gabriella Bulloch, Qingsheng Peng, Ching-Yu Cheng, Mingguang He, Honghua Yu, Zhuoting Zhu\",\"doi\":\"10.1167/tvst.13.11.26\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We investigated the association between metabolically healthy obesity (MHO) and retinal age gap and explored potential sex differences in this association.</p><p><strong>Methods: </strong>This study included 30,335 participants from the UK Biobank. Body mass index (BMI) was classified into normal weight, overweight, and obesity. Metabolic health (MH) was defined as meeting the following criteria: systolic blood pressure of <130 mm Hg, no antihypertensive drugs, waist-to-hip ratio of <0.95 for women or 1.03 for men, and the absence of diabetes. Participants were categorized as MH normal weight (MHN), MH overweight (MHOW), MHO, metabolically unhealthy normal weight, metabolically unhealthy (MU) overweight, and MU obesity. Retinal age gap was defined as the difference between retinal age and chronological age. Linear regression models were used to investigate the association of metabolic phenotypes of obesity with retinal age gap.</p><p><strong>Results: </strong>Compared with MHN, individuals with MHOW (β, 0.17; 95% confidence interval [CI], 0.01-0.32; P = 0.039) and MHO (β, 0.23; 95% CI, 0.02-0.44; P = 0.031) were associated with increased retinal age gap. Furthermore, individuals classified as metabolic unhealthy were also associated with higher retinal age gap, irrespective of body mass index categories (β for MU normal weight, 0.23; 95% CI, 0.08-0.38; P = 0.003; β for MU overweight: 0.31; 95% CI, 0.18-0.45; P < 0.001; β for MU obesity, 0.50; 95% CI, 0.36-0.65; P < 0.001). No significant sex difference was observed in the association between metabolic phenotypes of obesity and retinal age gap (all P for interaction > 0.05).</p><p><strong>Conclusions: </strong>MHOW and MHO were associated significantly with an increased retinal age gap compared with MHN individuals. Weight management should be recommended for individuals who are overweight or obese, even in the absence of metabolic unhealth.</p><p><strong>Translational relevance: </strong>Retinal age gap provides a simple tool for identifying early health risks for MHOW and MHO individuals.</p>\",\"PeriodicalId\":23322,\"journal\":{\"name\":\"Translational Vision Science & Technology\",\"volume\":\"13 11\",\"pages\":\"26\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585067/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Vision Science & Technology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1167/tvst.13.11.26\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.13.11.26","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Associations of Metabolically Healthy Obesity and Retinal Age Gap.
Purpose: We investigated the association between metabolically healthy obesity (MHO) and retinal age gap and explored potential sex differences in this association.
Methods: This study included 30,335 participants from the UK Biobank. Body mass index (BMI) was classified into normal weight, overweight, and obesity. Metabolic health (MH) was defined as meeting the following criteria: systolic blood pressure of <130 mm Hg, no antihypertensive drugs, waist-to-hip ratio of <0.95 for women or 1.03 for men, and the absence of diabetes. Participants were categorized as MH normal weight (MHN), MH overweight (MHOW), MHO, metabolically unhealthy normal weight, metabolically unhealthy (MU) overweight, and MU obesity. Retinal age gap was defined as the difference between retinal age and chronological age. Linear regression models were used to investigate the association of metabolic phenotypes of obesity with retinal age gap.
Results: Compared with MHN, individuals with MHOW (β, 0.17; 95% confidence interval [CI], 0.01-0.32; P = 0.039) and MHO (β, 0.23; 95% CI, 0.02-0.44; P = 0.031) were associated with increased retinal age gap. Furthermore, individuals classified as metabolic unhealthy were also associated with higher retinal age gap, irrespective of body mass index categories (β for MU normal weight, 0.23; 95% CI, 0.08-0.38; P = 0.003; β for MU overweight: 0.31; 95% CI, 0.18-0.45; P < 0.001; β for MU obesity, 0.50; 95% CI, 0.36-0.65; P < 0.001). No significant sex difference was observed in the association between metabolic phenotypes of obesity and retinal age gap (all P for interaction > 0.05).
Conclusions: MHOW and MHO were associated significantly with an increased retinal age gap compared with MHN individuals. Weight management should be recommended for individuals who are overweight or obese, even in the absence of metabolic unhealth.
Translational relevance: Retinal age gap provides a simple tool for identifying early health risks for MHOW and MHO individuals.
期刊介绍：
Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO.
The journal covers a broad spectrum of work, including but not limited to:
Applications of stem cell technology for regenerative medicine,
Development of new animal models of human diseases,
Tissue bioengineering,
Chemical engineering to improve virus-based gene delivery,
Nanotechnology for drug delivery,
Design and synthesis of artificial extracellular matrices,
Development of a true microsurgical operating environment,
Refining data analysis algorithms to improve in vivo imaging technology,
Results of Phase 1 clinical trials,
Reverse translational ("bedside to bench") research.
TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.
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