Anke Kohlenberg, Olov Svartström, Petra Apfalter, Rainer Hartl, Pierre Bogaerts, Te-Din Huang, Katerina Chudejova, Lucia Malisova, Jessica Eisfeld, Mirco Sandfort, Anette M Hammerum, Louise Roer, Kati Räisänen, Laurent Dortet, Rémy A Bonnin, Ákos Tóth, Kinga Tóth, Christina Clarke, Martin Cormican, Algirdas Griškevičius, Kirstin Khonyongwa, Marie Meo, Baiba Niedre-Otomere, Reinis Vangravs, Antoni Pa Hendrickx, Daan W Notermans, Ørjan Samuelsen, Manuela Caniça, Vera Manageiro, Vilhelm Müller, Barbro Mäkitalo, Urška Kramar, Mateja Pirs, Daniel Palm, Dominique L Monnet, Erik Alm, Marius Linkevicius
{"title":"携带碳青霉烯酶基因的大肠埃希菌 ST131 的出现，欧洲联盟/欧洲经济区，2012 年 8 月至 2024 年 5 月。","authors":"Anke Kohlenberg, Olov Svartström, Petra Apfalter, Rainer Hartl, Pierre Bogaerts, Te-Din Huang, Katerina Chudejova, Lucia Malisova, Jessica Eisfeld, Mirco Sandfort, Anette M Hammerum, Louise Roer, Kati Räisänen, Laurent Dortet, Rémy A Bonnin, Ákos Tóth, Kinga Tóth, Christina Clarke, Martin Cormican, Algirdas Griškevičius, Kirstin Khonyongwa, Marie Meo, Baiba Niedre-Otomere, Reinis Vangravs, Antoni Pa Hendrickx, Daan W Notermans, Ørjan Samuelsen, Manuela Caniça, Vera Manageiro, Vilhelm Müller, Barbro Mäkitalo, Urška Kramar, Mateja Pirs, Daniel Palm, Dominique L Monnet, Erik Alm, Marius Linkevicius","doi":"10.2807/1560-7917.ES.2024.29.47.2400727","DOIUrl":null,"url":null,"abstract":"<p><p>Analysis of 594 isolates of <i>Escherichia coli</i> sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were <i>bla</i> <sub>OXA-244</sub> (n = 230) and <i>bla</i> <sub>OXA-48</sub> (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying <i>bla</i> <sub>OXA-244</sub> have increased rapidly since 2021. The increasing detection of carbapenemase genes in the <i>E. coli</i> high-risk lineage ST131 is a public health concern.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":7.8000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583312/pdf/","citationCount":"0","resultStr":"{\"title\":\"Emergence of <i>Escherichia coli</i> ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024.\",\"authors\":\"Anke Kohlenberg, Olov Svartström, Petra Apfalter, Rainer Hartl, Pierre Bogaerts, Te-Din Huang, Katerina Chudejova, Lucia Malisova, Jessica Eisfeld, Mirco Sandfort, Anette M Hammerum, Louise Roer, Kati Räisänen, Laurent Dortet, Rémy A Bonnin, Ákos Tóth, Kinga Tóth, Christina Clarke, Martin Cormican, Algirdas Griškevičius, Kirstin Khonyongwa, Marie Meo, Baiba Niedre-Otomere, Reinis Vangravs, Antoni Pa Hendrickx, Daan W Notermans, Ørjan Samuelsen, Manuela Caniça, Vera Manageiro, Vilhelm Müller, Barbro Mäkitalo, Urška Kramar, Mateja Pirs, Daniel Palm, Dominique L Monnet, Erik Alm, Marius Linkevicius\",\"doi\":\"10.2807/1560-7917.ES.2024.29.47.2400727\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Analysis of 594 isolates of <i>Escherichia coli</i> sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were <i>bla</i> <sub>OXA-244</sub> (n = 230) and <i>bla</i> <sub>OXA-48</sub> (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying <i>bla</i> <sub>OXA-244</sub> have increased rapidly since 2021. The increasing detection of carbapenemase genes in the <i>E. coli</i> high-risk lineage ST131 is a public health concern.</p>\",\"PeriodicalId\":12161,\"journal\":{\"name\":\"Eurosurveillance\",\"volume\":\"29 47\",\"pages\":\"\"},\"PeriodicalIF\":7.8000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583312/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eurosurveillance\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400727\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eurosurveillance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400727","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
对来自 17 个欧盟/欧洲经济区国家的 594 个携带碳青霉烯酶基因的大肠埃希菌序列类型（ST）131 及其单基因座变异株分离物进行分析后发现，这些分离物中有 18 个碳青霉烯酶变异株，主要属于 ST131 A 和 C 支系。自 2021 年以来，携带 bla OXA-244 的分离株迅速增加。在大肠杆菌高风险菌系ST131中检测到越来越多的碳青霉烯酶基因是一个公共卫生问题。
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024.
Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were blaOXA-244 (n = 230) and blaOXA-48 (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying blaOXA-244 have increased rapidly since 2021. The increasing detection of carbapenemase genes in the E. coli high-risk lineage ST131 is a public health concern.
期刊介绍：
Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.
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