探索从氧化应激到卵巢衰老的潜在途径。

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2024-11-21 DOI:10.1111/jog.16166
Hiroshi Kobayashi, Shogo Imanaka
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引用次数: 0

摘要

目的:在发达国家,越来越多的妇女推迟生育,导致对不孕不育治疗需求的增加和辅助生殖技术的广泛使用。然而,尽管体外受精(IVF)技术不断进步,40 岁以上妇女的活产率仍然不理想。线粒体功能障碍被广泛认为是卵母细胞数量和质量随年龄增长而下降的关键因素。我们旨在总结目前对卵巢衰老的认识,尤其关注损害线粒体功能的途径,并探讨未来的研究方向:方法:检索电子数据库中截至 2024 年 6 月 30 日发表的文章:持续的排卵、黄体溶解和月经会引发外源性活性氧(ROS)介导的氧化应激,从而损伤线粒体DNA。这反过来又会降低核基因表达,损害线粒体氧化磷酸化,减少 5'三磷酸腺苷的产生。持续的内源性 ROS 会进一步加剧线粒体 DNA 损伤和非整倍体,最终造成不可逆的染色体异常,导致卵母细胞衰老:我们已经描述了从氧化应激到卵巢衰老的途径。卵巢衰老的早期检测和管理为改进试管婴儿治疗策略带来了挑战和机遇。
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Exploring potential pathways from oxidative stress to ovarian aging.

Aim: In developed nations, women have increasingly deferred childbearing, leading to a rise in demand for infertility treatments and the widespread use of assisted reproductive technologies. However, despite advancements in in vitro fertilization (IVF), live birth rates among women over 40 remain suboptimal. Mitochondrial dysfunction is widely recognized as a key factor in the processes driving the age-related deterioration in both the quantity and quality of oocytes. We aim to summarize current insights into ovarian aging, with a particular focus on pathways that impair mitochondrial function, and explore directions for future research.

Methods: Electronic databases were searched for articles published up to June 30, 2024.

Results: Ongoing ovulation, luteolysis, and menstruation trigger exogenous reactive oxygen species (ROS)-mediated oxidative stress that damages mitochondrial DNA. This, in turn, reduces nuclear gene expression, compromises mitochondrial oxidative phosphorylation, and diminishes adenosine 5' triphosphate production. Persistent endogenous ROS further exacerbate mitochondrial DNA damage and aneuploidy, ultimately causing irreversible chromosomal abnormalities, leading to oocyte aging.

Conclusions: We have delineated the pathway from oxidative stress to ovarian aging. Early detection and management of ovarian aging present challenges and opportunities to enhance IVF treatment strategies.

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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
376
审稿时长
3-6 weeks
期刊介绍: The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
期刊最新文献
Letter to "Outstanding performance of ChatGPT on the obstetrics and gynecology board certification examination in Japan: Document and image-based questions analysis". Japan Society of Obstetrics and Gynecology revised diagnostic criteria for polycystic ovary syndrome: JSOG2024 criteria. Causes and clinical characteristics of women with primary amenorrhea and ovarian or gonadal disorders at a quaternary hospital. Exploring potential pathways from oxidative stress to ovarian aging. Primary splenic ectopic pregnancy: A case report and literature review of a rare issue.
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