尼日利亚一项前瞻性多中心队列研究:结直肠癌急诊就诊后的风险因素、治疗模式和生存结果分析》(Analysis of Risk Factors, Treatment Patterns, and Survival Outcomes After Emergency Presentation with Colorectal Cancer:尼日利亚前瞻性多中心队列研究》。

IF 2 3区 医学 Q3 ONCOLOGY Journal of Surgical Oncology Pub Date : 2024-11-21 DOI:10.1002/jso.27878
Adeniyi S Aderibigbe, Anna J Dare, Hannah L Kalvin, Olalekan Olasehinde, Funmilola Wuraola, Adewale Adisa, Adeleye Dorcas Omisore, Akinwumi O Komolafe, Oluwatosin Zainab Omoyiola, Chukwuma Eze Okereke, Aba Katung, Adedeji Egberoungbe, Olufemi Ariyibi, Samuel Adegboyega Olatoke, Ademola Adetoyese Adeyeye, Sulaiman Olayide Agodirin, Matthew Olumuyiwa Bojuwoye, James Oluwaleke Fayenuwo, Oluwabusayomi Roseline Ademakinwa, Dapo Osinowo, Abdul-Razak Lawal, Fatimah B Abdulkareem, Debra Goldman, Gregory Knapp, Shilpa Murthy, Rivka Kahn, Mithat Gonen, T Peter Kingham, Olusegun I Alatise
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引用次数: 0

摘要

背景和目标:尼日利亚有关结直肠癌(CRC)发病和预后的前瞻性数据有限:尼日利亚有关结直肠癌(CRC)发病和预后的前瞻性数据有限,但晚期急诊发病被认为很常见:方法:纳入了 6 年来在 6 个地点就诊的连续 CRC 患者。采用逻辑回归方法评估了急诊的风险因素。采用 Kaplan-Meier 方法和对数秩检验比较了急诊和择期患者的总生存率(OS):535名患者中,30.7%为急诊患者。中位年龄为 56 岁,55% 为男性,5.0% 有癌症家族史。急诊患者多为近端癌症(42.1% 对 24.0%)、IV 期疾病(61.6% 对 40.2%;P 结论:尼日利亚急诊癌症患者的生存率较低:尼日利亚的急诊 CRC 患者的 OS 不如择期患者。癌症控制工作的重点应放在加快癌症检测、早期发现、诊断和治疗上。
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Analysis of Risk Factors, Treatment Patterns, and Survival Outcomes After Emergency Presentation With Colorectal Cancer: A Prospective Multicenter Cohort Study in Nigeria.

Background and objectives: Prospective data on presentation and outcomes of colorectal cancer (CRC) in Nigeria are limited; however, emergency presentation with advanced disease is thought common.

Methods: Consecutive CRC patients presenting at six sites over 6 years were included. Risk factors for emergency presentation were evaluated using logistic regression methods. Overall survival (OS) was compared between emergent and elective patients using Kaplan-Meier methods and the log-rank test.

Results: Of 535 patients, 30.7% presented emergently. Median age was 56 years, 55% were men, and 5.0% reported a cancer family history. Emergency patients had more proximal cancers (42.1% vs. 24.0%), Stage IV disease (61.6% vs. 40.2%; p < 0.001), lower household income (₦35 000/month vs. ₦50 000/month), lower education levels (p = 0.008) and accessed care with nonmotorized transport (50.6% vs. 37.2%; p = 0.005). Median OS was shorter in the emergency group (6.4 vs. 17.4 months; p < 0.001). Across clinical stages, emergency presentation was associated with worse OS (Stage IV median OS 4.8 vs. 9.4 months; p = 0.002). Surgery improved survival in both groups, although emergency patients had higher 30-day postoperative mortality (23.2% vs. 9.1%; p < 0.001).

Conclusions: Emergent Nigerian CRC patients have worse OS than elective patients. Cancer control efforts should focus on faster cancer detection, early presentation, diagnosis, and treatment.

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来源期刊
CiteScore
4.70
自引率
4.00%
发文量
367
审稿时长
2 months
期刊介绍: The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.
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