阻塞性睡眠呼吸暂停与慢性鼻窦炎:了解 OSA 对 CRS 疾病负担的影响。

IF 2.6 3区 医学 Q1 OTORHINOLARYNGOLOGY Otolaryngology- Head and Neck Surgery Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI:10.1002/ohn.934
Emily Garvey, Alexander Duffy, Sruti Tekumalla, Bita Naimi, Chase Kahn, Angela Yang, Zachary Urdang, Douglas Farquhar, Marc Rosen, Gurston G Nyquist, Elina Toskala, Mindy Rabinowitz
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引用次数: 0

摘要

目的:评估阻塞性睡眠呼吸暂停(OSA)对慢性鼻炎(CRS)严重程度的影响:评估阻塞性睡眠呼吸暂停(OSA)对慢性鼻窦炎(CRS)严重程度的影响:研究设计:回顾性数据库审查:背景:TriNetX 美国数据库:对 TriNetX US 协作网络数据库中的 OSA、CRS 和合并 OSA 的 CRS(CRS-OSA)患者队列进行查询。数据包括人口统计学特征、通过内窥镜鼻窦手术(ESS)、抗生素和口服类固醇的使用率评估 CRS 的严重程度。为了考虑人口统计学和临床变量的差异,进行了倾向得分匹配:查询结果显示,共有 1818879 名 CRS 患者、481144 名 OSA 患者和 93153 名 CRS-OSA 患者。与 CRS 或 OSA 患者相比,OSA-CRS 患者的高血压、糖尿病、肥胖和哮喘发病率较高(P 结论:OSA-CRS 患者的高血压、糖尿病、肥胖和哮喘发病率较高):与 CRS 或 OSA 患者相比,CRS-OSA 患者同时患有这两种疾病的比例更高。OSA 与 CRS 患者使用 ESS、抗生素和类固醇的风险增加有关。OSA的治疗似乎与CRS的预后有关,但还需要进一步的研究。
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Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden.

Objective: Assess the impact of obstructive sleep apnea (OSA) on chronic rhinosinusitis (CRS) severeity.

Study design: Retrospective database review.

Setting: TriNetX US database.

Methods: TriNetX US Collaborative Network database was queried for cohorts of patients with OSA, CRS, and CRS with comorbid OSA (CRS-OSA). Data included demographics, CRS severity was assessed via rates of endoscopic sinus surgery (ESS), antibiotic, and oral steroid use. Propensity score matching was performed to account for differences in demographics and clinical variables.

Results: The query identified 1,818,879 patients with CRS, 481144 with OSA, and 93,153 CRS-OSA patients. OSA-CRS patients had higher rates of hypertension, diabetes mellitus, obesity, and asthma than either CRS or OSA populations (P < 0.0001). CRS-OSA patients demonstrated higher rates of ESS (odds ratio [OR]: 1.91, 1.82-2.02, P < 0.0001), antibiotic (OR: 1.90, 1.81-1.96, P < 0.001), and oral steroid use (OR: 2.23, 2.16-2.28, P < 0.001) compared to CRS-only patients. CRS-OSA patients not on continuous positive airway pressure had higher utilization of antibiotics (OR: 3.24, 2.82-3.71, P < 0.0001) and steroids (OR: 2.28, 2.05-2.55, P < 0.0001) than nonutilizers. CRS-OSA patients with sleep-related surgical interventions required fewer antibiotic courses (OR: 1.93, 1.62-2.28, P < 0.0001).

Conclusion: CRS-OSA patients experience higher rates of comorbidities associated with both diseases than those with CRS or OSA alone. OSA was associated with an increased risk of ESS, antibiotic, and steroid use in patients with CRS. There appears to be a correlation with treatment of OSA and CRS outcomes, however, further studies are required.

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来源期刊
Otolaryngology- Head and Neck Surgery
Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学
CiteScore
6.70
自引率
2.90%
发文量
250
审稿时长
2-4 weeks
期刊介绍: Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.
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