纳米管介导的线粒体转移：为 T 细胞提供动力！

IF 13.1 1区医学 Q1 IMMUNOLOGY Trends in Immunology Pub Date : 2024-11-20 DOI:10.1016/j.it.2024.11.001

Cosima T Baldari

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引用次数: 0

摘要

基于T细胞的免疫疗法的成功受到衰竭的限制，而衰竭与线粒体功能障碍有关。鲍德温及其同事的研究表明，骨髓基质细胞（BMSCs）利用纳米管将线粒体转移到T细胞，从而增加线粒体的质量和功能，提高抗肿瘤疗效。这些成果为基于细胞器的抗癌疗法铺平了道路。

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Nanotube-mediated mitochondrial transfer: power to the T cells!

The success of T cell-based immunotherapies is limited by exhaustion, which is associated with mitochondrial dysfunction. Baldwin and colleagues show that bone marrow stromal cells (BMSCs) use nanotubes to transfer mitochondria to T cells, which increases mitochondria mass and fitness and boosts antitumor efficacy. The results pave the way to organelle-based therapies against cancer.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.

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