抗抑郁分子丁螺环酮的后期功能化。

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED Molecular Diversity Pub Date : 2024-11-23 DOI:10.1007/s11030-024-11029-x

Yalin Guo, Debin Yang, Bo Hu, Yongtao Duan, Yibing Cheng, Yu Tang, Caili Guo, Yuanzhe Li, Bing Yu

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引用次数: 0

摘要

丁螺环酮（Buspirone）是一种成熟的抗焦虑药，由于其独特的药理特征和有效调节 5-羟色胺受体的能力，它作为抗抑郁药的潜在作用受到了关注。后期功能化被认为是药物合成中的一种关键策略，可提高现有分子的疗效。本综述总结了适用于丁螺环酮的各种后期功能化技术，包括光催化、金属催化和酶催化反应。

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Late-stage-functionalization of anti-depressant molecule buspirone.

Buspirone, a well-established anxiolytic agent, has gained attention for its potential role as an antidepressant, primarily due to its unique pharmacological profile and the ability to modulate serotonin receptors effectively. Late-stage functionalization is considered as a pivotal strategy in drug synthesis that enhances the therapeutic efficacy of existing molecules. This review summarizes various late-stage functionalization techniques applicable to Buspirone, including photocatalyzed, metal-catalyzed, and enzyme-catalyzed reactions.

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;