{"title":"使用银纳米粒子装饰的 miswak 衍生碳量子点快速愈合伤口。","authors":"Esra Hacımüftüoğlu, Fatma Yesilyurt, Aynur Babagil, Ali Sefa Mendil, Hayrunnisa Nadaroglu","doi":"10.1016/j.jtv.2024.10.008","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oxidants are pivotal in combating aging, cancer, and weakened immunity. Shielding the body from free radicals is crucial for an extended lifespan. The development of effective systems for this purpose is paramount. This study investigated the impact of miswak carbon quantum dots (M-CQD) on radical elimination and wound healing.</p><p><strong>Methods: </strong>M-CQD were synthesized via a hydrothermal method using miswak water extract at 220 °C for 8 h. Chitosan-modified Ag@M-CS-CQD were produced. The characterization involved SEM, XRD, and FTIR analysis. M-CQD and Ag@M-CS-CQD emitted bluish-white light under UV excitation.</p><p><strong>Results: </strong>At 10, 30, and 50 μg/mL, DPPH• and phosphomolybdenum complex radicals inhibited 67 %, 82 %, and 98 %, respectively, with Ag@M-CS-CQD demonstrating the highest activity. The IC<sub>50</sub> values for M-CQD and Ag@M-CS-CQD were 0.91 ± 0.010 and 1.183 ± 0.033, respectively. Ag@M-CS-CQD NPs displayed remarkable wound healing efficacy at 20 μg/L, highlighting their potential as potent antioxidants. Immunohistochemical analyzes also showed that Ag@M-CS-CQD increased TGF-β expression levels, which was associated with wound healing.</p><p><strong>Conclusion: </strong>This eco-friendly synthesis method yielded Ag@M-CS-CQD, which exhibited robust antioxidant properties and efficacy in wound healing. This study emphasizes the potential of these nanoparticles as effective therapeutic agents.</p>","PeriodicalId":17392,"journal":{"name":"Journal of tissue viability","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rapid wound healing with silver nanoparticle-decorated miswak-derived carbon quantum dots.\",\"authors\":\"Esra Hacımüftüoğlu, Fatma Yesilyurt, Aynur Babagil, Ali Sefa Mendil, Hayrunnisa Nadaroglu\",\"doi\":\"10.1016/j.jtv.2024.10.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Oxidants are pivotal in combating aging, cancer, and weakened immunity. Shielding the body from free radicals is crucial for an extended lifespan. The development of effective systems for this purpose is paramount. This study investigated the impact of miswak carbon quantum dots (M-CQD) on radical elimination and wound healing.</p><p><strong>Methods: </strong>M-CQD were synthesized via a hydrothermal method using miswak water extract at 220 °C for 8 h. Chitosan-modified Ag@M-CS-CQD were produced. The characterization involved SEM, XRD, and FTIR analysis. M-CQD and Ag@M-CS-CQD emitted bluish-white light under UV excitation.</p><p><strong>Results: </strong>At 10, 30, and 50 μg/mL, DPPH• and phosphomolybdenum complex radicals inhibited 67 %, 82 %, and 98 %, respectively, with Ag@M-CS-CQD demonstrating the highest activity. The IC<sub>50</sub> values for M-CQD and Ag@M-CS-CQD were 0.91 ± 0.010 and 1.183 ± 0.033, respectively. Ag@M-CS-CQD NPs displayed remarkable wound healing efficacy at 20 μg/L, highlighting their potential as potent antioxidants. Immunohistochemical analyzes also showed that Ag@M-CS-CQD increased TGF-β expression levels, which was associated with wound healing.</p><p><strong>Conclusion: </strong>This eco-friendly synthesis method yielded Ag@M-CS-CQD, which exhibited robust antioxidant properties and efficacy in wound healing. This study emphasizes the potential of these nanoparticles as effective therapeutic agents.</p>\",\"PeriodicalId\":17392,\"journal\":{\"name\":\"Journal of tissue viability\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-10-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of tissue viability\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jtv.2024.10.008\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of tissue viability","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jtv.2024.10.008","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Rapid wound healing with silver nanoparticle-decorated miswak-derived carbon quantum dots.
Background: Oxidants are pivotal in combating aging, cancer, and weakened immunity. Shielding the body from free radicals is crucial for an extended lifespan. The development of effective systems for this purpose is paramount. This study investigated the impact of miswak carbon quantum dots (M-CQD) on radical elimination and wound healing.
Methods: M-CQD were synthesized via a hydrothermal method using miswak water extract at 220 °C for 8 h. Chitosan-modified Ag@M-CS-CQD were produced. The characterization involved SEM, XRD, and FTIR analysis. M-CQD and Ag@M-CS-CQD emitted bluish-white light under UV excitation.
Results: At 10, 30, and 50 μg/mL, DPPH• and phosphomolybdenum complex radicals inhibited 67 %, 82 %, and 98 %, respectively, with Ag@M-CS-CQD demonstrating the highest activity. The IC50 values for M-CQD and Ag@M-CS-CQD were 0.91 ± 0.010 and 1.183 ± 0.033, respectively. Ag@M-CS-CQD NPs displayed remarkable wound healing efficacy at 20 μg/L, highlighting their potential as potent antioxidants. Immunohistochemical analyzes also showed that Ag@M-CS-CQD increased TGF-β expression levels, which was associated with wound healing.
Conclusion: This eco-friendly synthesis method yielded Ag@M-CS-CQD, which exhibited robust antioxidant properties and efficacy in wound healing. This study emphasizes the potential of these nanoparticles as effective therapeutic agents.
期刊介绍：
The Journal of Tissue Viability is the official publication of the Tissue Viability Society and is a quarterly journal concerned with all aspects of the occurrence and treatment of wounds, ulcers and pressure sores including patient care, pain, nutrition, wound healing, research, prevention, mobility, social problems and management.
The Journal particularly encourages papers covering skin and skin wounds but will consider articles that discuss injury in any tissue. Articles that stress the multi-professional nature of tissue viability are especially welcome. We seek to encourage new authors as well as well-established contributors to the field - one aim of the journal is to enable all participants in tissue viability to share information with colleagues.
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